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Front Physiol. 2021 Dec 15;12:740806. doi: 10.3389/fphys.2021.740806. eCollection 2021.

Leptin Gene Protects Against Cold Stress in Antarctic Toothfish.

Frontiers in physiology

Ying Wang, Huamin Wang, Linghong Hu, Liangbiao Chen

Affiliations

  1. International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China.
  2. Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.
  3. Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai, China.

PMID: 34975517 PMCID: PMC8715755 DOI: 10.3389/fphys.2021.740806

Abstract

Leptin is a cytokine-like peptide, predominantly biosynthesized in adipose tissue, which plays an important role in regulating food intake, energy balance and reproduction in mammals. However, how it may have been modified to enable life in the chronic cold is unclear. Here, we identified a

Copyright © 2021 Wang, Wang, Hu and Chen.

Keywords: Dissostichus mawsoni; STAT3 signaling; leptin-a; p53; polar fish; positive selection

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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