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Peng J, Boekhoff S, Eveslage M, et al. Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients. Front Endocrinol (Lausanne). 2021;12:772856doi: 10.3389/fendo.2021.772856.
Peng, J., Boekhoff, S., Eveslage, M., Bison, B., Sowithayasakul, P., Friedrich, C., & Müller, H. L. (2021). Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients. Frontiers in endocrinology, 12772856. https://doi.org/10.3389/fendo.2021.772856
Peng, Junxiang, et al. "Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients." Frontiers in endocrinology vol. 12 (2021): 772856. doi: https://doi.org/10.3389/fendo.2021.772856
Peng J, Boekhoff S, Eveslage M, Bison B, Sowithayasakul P, Friedrich C, Müller HL. Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients. Front Endocrinol (Lausanne). 2021 Dec 16;12:772856. doi: 10.3389/fendo.2021.772856. eCollection 2021. PMID: 34975750; PMCID: PMC8716728.
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Front Endocrinol (Lausanne). 2021 Dec 16;12:772856. doi: 10.3389/fendo.2021.772856. eCollection 2021.

Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients.

Frontiers in endocrinology

Junxiang Peng, Svenja Boekhoff, Maria Eveslage, Brigitte Bison, Panjarat Sowithayasakul, Carsten Friedrich, Hermann L Müller

Affiliations

  1. Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Carl von Ossietzky University, Oldenburg, Germany.
  2. Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  3. Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
  4. Department of Neuroradiology, University Hospital, Würzburg, Germany.
  5. Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

PMID: 34975750 PMCID: PMC8716728 DOI: 10.3389/fendo.2021.772856

Abstract

BACKGROUND: Severe obesity and tumor relapse/progression have impact on long-term prognosis in pediatric brain tumor patients.

METHODS: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on magnetic-resonance imaging (MRI) follow-up monitoring as a parameter for assessment of nuchal adipose tissue in 177 brain tumor patients (40 World Health Organization (WHO) grade 1-2 brain tumor; 31 grade 3-4 brain tumor; 106 craniopharyngioma), and 53 healthy controls. Furthermore, body mass index (BMI), waist-to-height ratio, caliper-measured skinfold thickness, and blood pressure were analyzed for association with NST.

RESULTS: Craniopharyngioma patients showed higher NST, BMI, waist-to-height ratio, and caliper-measured skinfold thickness when compared to other brain tumors and healthy controls. WHO grade 1-2 brain tumor patients were observed with higher BMI, waist circumference and triceps caliper-measured skinfold thickness when compared to WHO grade 3-4 brain tumor patients. NST correlated with BMI, waist-to-height ratio, and caliper-measured skinfold thickness. NST, BMI and waist-to-height ratio were associated with increased blood pressure. In craniopharyngioma patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased.

CONCLUSIONS: NST could serve as a novel useful marker for regional nuchal adipose tissue. NST is highly associated with body mass and waist-to-height ratio, and easily measurable in routine MRI monitoring of brain tumor patients.

Copyright © 2021 Peng, Boekhoff, Eveslage, Bison, Sowithayasakul, Friedrich and Müller.

Keywords: craniopharyngioma; hypothalamic involvement; obesity; pediatric brain tumor; skinfold thickness

Conflict of interest statement

HM has received reimbursement of participation fees for scientific meetings and continuing medical education events from the following companies: Ferring, Lilly, Pfizer, Sandoz/Hexal, Novo Nordisk, IP

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