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Russo E, Laffranchi M, Tomaipitinca L, et al. NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment. Front Immunol. 2021;12:787116doi: 10.3389/fimmu.2021.787116.
Russo, E., Laffranchi, M., Tomaipitinca, L., Del Prete, A., Santoni, A., Sozzani, S., & Bernardini, G. (2021). NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment. Frontiers in immunology, 12787116. https://doi.org/10.3389/fimmu.2021.787116
Russo, Eleonora, et al. "NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment." Frontiers in immunology vol. 12 (2021): 787116. doi: https://doi.org/10.3389/fimmu.2021.787116
Russo E, Laffranchi M, Tomaipitinca L, Del Prete A, Santoni A, Sozzani S, Bernardini G. NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment. Front Immunol. 2021 Dec 17;12:787116. doi: 10.3389/fimmu.2021.787116. eCollection 2021. PMID: 34975880; PMCID: PMC8718597.
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Front Immunol. 2021 Dec 17;12:787116. doi: 10.3389/fimmu.2021.787116. eCollection 2021.

NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment.

Frontiers in immunology

Eleonora Russo, Mattia Laffranchi, Luana Tomaipitinca, Annalisa Del Prete, Angela Santoni, Silvano Sozzani, Giovanni Bernardini

Affiliations

  1. Department of Molecular Medicine, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
  2. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
  3. Humanitas Clinical and Research Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, Italy.
  4. Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pozzilli, Italy.

PMID: 34975880 PMCID: PMC8718597 DOI: 10.3389/fimmu.2021.787116

Abstract

NK cells are innate lymphoid cells endowed with cytotoxic capacity that play key roles in the immune surveillance of tumors. Increasing evidence indicates that NK cell anti-tumor response is shaped by bidirectional interactions with myeloid cell subsets such as dendritic cells (DCs) and macrophages. DC-NK cell crosstalk in the tumor microenvironment (TME) strongly impacts on the overall NK cell anti-tumor response as DCs can affect NK cell survival and optimal activation while, in turn, NK cells can stimulate DCs survival, maturation and tumor infiltration through the release of soluble factors. Similarly, macrophages can either shape NK cell differentiation and function by expressing activating receptor ligands and/or cytokines, or they can contribute to the establishment of an immune-suppressive microenvironment through the expression and secretion of molecules that ultimately lead to NK cell inhibition. Consequently, the exploitation of NK cell interaction with DCs or macrophages in the tumor context may result in an improvement of efficacy of immunotherapeutic approaches.

Copyright © 2021 Russo, Laffranchi, Tomaipitinca, Del Prete, Santoni, Sozzani and Bernardini.

Keywords: NK cells; chemokine receptors; dendritic cells; immunotherapy; macrophages; tumor microenvironment

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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