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Ruan JW, Zhao JF, Li XL, et al. Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps. Front Cell Dev Biol. 2021;9:793073doi: 10.3389/fcell.2021.793073.
Ruan, J. W., Zhao, J. F., Li, X. L., Liao, B., Pan, L., Zhu, K. Z., Feng, Q. M., Liu, J. X., Yu, Z. E., Song, J., Wang, H., & Liu, Z. (2021). Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps. Frontiers in cell and developmental biology, 9793073. https://doi.org/10.3389/fcell.2021.793073
Ruan, Jian-Wen, et al. "Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps." Frontiers in cell and developmental biology vol. 9 (2021): 793073. doi: https://doi.org/10.3389/fcell.2021.793073
Ruan JW, Zhao JF, Li XL, Liao B, Pan L, Zhu KZ, Feng QM, Liu JX, Yu ZE, Song J, Wang H, Liu Z. Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps. Front Cell Dev Biol. 2021 Dec 17;9:793073. doi: 10.3389/fcell.2021.793073. eCollection 2021. PMID: 34977034; PMCID: PMC8718617.
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Front Cell Dev Biol. 2021 Dec 17;9:793073. doi: 10.3389/fcell.2021.793073. eCollection 2021.

Characterizing the Neutrophilic Inflammation in Chronic Rhinosinusitis With Nasal Polyps.

Frontiers in cell and developmental biology

Jian-Wen Ruan, Jie-Fang Zhao, Xue-Li Li, Bo Liao, Li Pan, Ke-Zhang Zhu, Qi-Miao Feng, Jin-Xin Liu, Zi-E Yu, Jia Song, Hai Wang, Zheng Liu

Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 34977034 PMCID: PMC8718617 DOI: 10.3389/fcell.2021.793073

Abstract

The mechanisms underlying neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly investigated. This study aimed to examine the factors that contribute to tissue neutrophilia in CRSwNP. The numbers of neutrophils and active caspase-3-positive apoptotic neutrophils in sinonasal tissues were assessed via immunofluorescence staining. The 95th percentile of tissue neutrophil numbers in control subjects was selected as a cut-off to define neutrophil-high (Neu-high) or neutrophil-low (Neu-low) nasal polyps (NPs). The levels of 34 inflammatory mediators in sinonasal tissues were analyzed using Bio-Plex assay. Purified human peripheral blood neutrophils were incubated with nasal tissue homogenates, and the apoptotic neutrophils were assessed

Copyright © 2021 Ruan, Zhao, Li, Liao, Pan, Zhu, Feng, Liu, Yu, Song, Wang and Liu.

Keywords: apoptosis; chronic rhinosinusitis with nasal polyps; granulocyte colonystimulating factor; inflammation; neutrophil

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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