0.05).CONCLUSIONS: In patients with TAAs without a diagnosis of HTN, central HTN is prevalent, and higher cBP is associated with larger aneurysms and faster aneurysm growth." />
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Rooprai J, Boodhwani M, Beauchesne L, et al. Central Hypertension in Patients With Thoracic Aortic Aneurysms: Prevalence and Association With Aneurysm Size and Growth. Am J Hypertens. 2022;35(1):79-86doi: 10.1093/ajh/hpaa183.
Rooprai, J., Boodhwani, M., Beauchesne, L., Chan, K. L., Dennie, C., Wells, G. A., & Coutinho, T. (2022). Central Hypertension in Patients With Thoracic Aortic Aneurysms: Prevalence and Association With Aneurysm Size and Growth. American journal of hypertension, 35(1), 79-86. https://doi.org/10.1093/ajh/hpaa183
Rooprai, Jasjit, et al. "Central Hypertension in Patients With Thoracic Aortic Aneurysms: Prevalence and Association With Aneurysm Size and Growth." American journal of hypertension vol. 35,1 (2022): 79-86. doi: https://doi.org/10.1093/ajh/hpaa183
Rooprai J, Boodhwani M, Beauchesne L, Chan KL, Dennie C, Wells GA, Coutinho T. Central Hypertension in Patients With Thoracic Aortic Aneurysms: Prevalence and Association With Aneurysm Size and Growth. Am J Hypertens. 2022 Jan 05;35(1):79-86. doi: 10.1093/ajh/hpaa183. PMID: 33759993.
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Am J Hypertens. 2022 Jan 05;35(1):79-86. doi: 10.1093/ajh/hpaa183.

Central Hypertension in Patients With Thoracic Aortic Aneurysms: Prevalence and Association With Aneurysm Size and Growth.

American journal of hypertension

Jasjit Rooprai, Munir Boodhwani, Luc Beauchesne, Kwan-Leung Chan, Carole Dennie, George A Wells, Thais Coutinho

Affiliations

  1. Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
  2. The Department of Surgery, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  3. The Department of Medicine, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  4. The Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada.
  5. School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
  6. Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  7. The Division of Cardiac Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

PMID: 33759993 DOI: 10.1093/ajh/hpaa183

Abstract

BACKGROUND: Hypertension (HTN) has the greatest population-attributable risk for aortic dissection and is highly prevalent among patients with thoracic aortic aneurysms (TAAs). Although HTN is diagnosed based on brachial blood pressure (bBP), central HTN (central systolic blood pressure [cSBP] ≥130 mm Hg) is of interest as it better reflects blood pressure (BP) in the aorta. We aimed to (i) evaluate the prevalence of central HTN among TAA patients without a diagnosis of HTN, and (ii) assess associations of bBP vs. central blood pressure (cBP) with aneurysm size and growth.

METHODS: One hundred and five unoperated subjects with TAAs were recruited. With validated methodology, cBP was assessed with applanation tonometry. Aneurysm size was assessed at baseline and follow-up using imaging modalities. Aneurysm growth rate was calculated in mm/year. Multivariable linear regression adjusted for potential confounders assessed associations of bBP and cBP with aneurysm size and growth.

RESULTS: Seventy-seven percent of participants were men and 49% carried a diagnosis of HTN. Among participants without diagnosis of HTN, 15% had central HTN despite normal bBP ("occult central HTN"). In these patients, higher central systolic BP (cSBP) and central pulse pressure (cPP) were independently associated with larger aneurysm size (β ± SE = 0.28 ± 0.11, P = 0.014 and cPP = 0.30 ± 0.11, P = 0.010, respectively) and future aneurysm growth (β ± SE = 0.022 ± 0.008, P = 0.013 and 0.024 ± 0.009, P = 0.008, respectively) while bBP was not (P > 0.05).

CONCLUSIONS: In patients with TAAs without a diagnosis of HTN, central HTN is prevalent, and higher cBP is associated with larger aneurysms and faster aneurysm growth.

© American Journal of Hypertension, Ltd 2021. All rights reserved. For Permissions, please email: [email protected].

Keywords: blood pressure; central hypertension; hypertension; thoracic aortic aneurysm

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