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Montejo L, Torrent C, Jiménez E, et al. Cognition in older adults with bipolar disorder: an isbd task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment. Bipolar Disord. 2022;doi: 10.1111/bdi.13175.
Montejo, L., Torrent, C., Jiménez, E., Martínez-Arán, A., Blumberg, H. P., Burdick, K. E., Chen, P., Dols, A., Eyler, L. T., Forester, B. P., Gatchel, J. R., Gildengers, A., Kessing, L. V., Miskowiak, K. W., Olagunju, A. T., Patrick, R. E., Schouws, S., Radua, J., Del Mar Bonnín, C., Vieta, E. (2022). Cognition in older adults with bipolar disorder: an isbd task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment. Bipolar disorders, . https://doi.org/10.1111/bdi.13175
Montejo, Laura, et al. "Cognition in older adults with bipolar disorder: an isbd task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment." Bipolar disorders vol. (2022). doi: https://doi.org/10.1111/bdi.13175
Montejo L, Torrent C, Jiménez E, Martínez-Arán A, Blumberg HP, Burdick KE, Chen P, Dols A, Eyler LT, Forester BP, Gatchel JR, Gildengers A, Kessing LV, Miskowiak KW, Olagunju AT, Patrick RE, Schouws S, Radua J, Del Mar Bonnín C, Vieta E. Cognition in older adults with bipolar disorder: an isbd task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment. Bipolar Disord. 2022 Jan 02; doi: 10.1111/bdi.13175. Epub 2022 Jan 02. PMID: 34978124.
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Bipolar Disord. 2022 Jan 02; doi: 10.1111/bdi.13175. Epub 2022 Jan 02.

Cognition in older adults with bipolar disorder: an isbd task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment.

Bipolar disorders

Laura Montejo, Carla Torrent, Esther Jiménez, Anabel Martínez-Arán, Hilary P Blumberg, Katherine E Burdick, Peijun Chen, Annemieke Dols, Lisa T Eyler, Brent P Forester, Jennifer R Gatchel, Ariel Gildengers, Lars Vedel Kessing, Kamilla W Miskowiak, Andrew T Olagunju, Regan E Patrick, Sigfried Schouws, Joaquim Radua, Caterina Del Mar Bonnín, Eduard Vieta,

Affiliations

  1. Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain.
  2. Mood Disorders Research Program, Yale School of Medicine, New Haven, CT, USA.
  3. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  4. Section of Geriatric Psychiatry, Department of Psychiatry & VISN10 Geriatric Research, Education and Clinical Center, VA Northeast Ohio Healthcare System Cleveland VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  5. GGZ inGeest, Department of Psychiatry, Amsterdam UMC, location VU Medical Center, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
  6. Department of Psychiatry, University of California, San Diego; Desert-Pacific Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System.
  7. Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA; Harvard Medical School, Boston, MA, USA.
  8. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  9. Copenhagen Affective Disorder research Center (CADIC), Psychiatric Center Copenhagen, Copenhagen, Denmark.
  10. Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
  11. Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, Canada.
  12. Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBERSAM, Madrid, Spain; Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Clinical Neuroscience, Stockholm Health Care Services, Stockholm County Council, Karolinska Institutet, Stockholm, Sweden.

PMID: 34978124 DOI: 10.1111/bdi.13175

Abstract

OBJECTIVES: We aim to characterize the cognitive performance in euthymic older adults with bipolar disorder (OABD) through a comprehensive neuropsychological assessment to obtain a detailed neuropsychological profile.

METHODS: We conducted a systematic search in MEDLINE/Pubmed, Cochrane, and PsycInfo databases. Original studies assessing cognitive function in OABD (age ≥ 50 years) containing, at a minimum, the domains of attention/processing speed, memory, and executive functions were included. A random-effects meta-analysis was conducted to summarize differences between patients and matched controls in each cognitive domain. We also conducted meta-regressions to estimate the impact of clinical and socio-demographic variables on these differences.

RESULTS: Eight articles, providing data for 328 euthymic OABD patients and 302 healthy controls, were included in the meta-analysis. OABD showed worse performance in comparison with healthy controls, with large significant effect sizes (Hedge's g from -0.77 to -0.89; p<0.001) in verbal learning and verbal and visual delayed memory. They also displayed statistically significant deficits, with moderate effect size, in processing speed, working memory, immediate memory, cognitive flexibility, verbal fluency, psychomotor function, executive functions, attention, inhibition and recognition (Hedge's g from -0.52 to -0.76; p<0.001), but not in language and visuo-construction domains. None of the examined variables were associated with these deficits.

CONCLUSIONS: Cognitive dysfunction is present in OABD, with important deficits in almost all cognitive domains, especially in the memory domain. Our results highlight the importance of including a routine complete neuropsychological assessment in OABD and also considering therapeutic strategies in OABD.

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