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Lo ZC, Sobota AE. Maintenance of a High Influenza Vaccination Rate and Improvement in Health Outcomes in a Pediatric Sickle Cell Disease Clinic. J Pediatr Hematol Oncol. 2022;44(1):e46-e50doi: 10.1097/MPH.0000000000002192.
Lo, Z. C., & Sobota, A. E. (2022). Maintenance of a High Influenza Vaccination Rate and Improvement in Health Outcomes in a Pediatric Sickle Cell Disease Clinic. Journal of pediatric hematology/oncology, 44(1), e46-e50. https://doi.org/10.1097/MPH.0000000000002192
Lo, Zachary C, and Sobota, Amy E. "Maintenance of a High Influenza Vaccination Rate and Improvement in Health Outcomes in a Pediatric Sickle Cell Disease Clinic." Journal of pediatric hematology/oncology vol. 44,1 (2022): e46-e50. doi: https://doi.org/10.1097/MPH.0000000000002192
Lo ZC, Sobota AE. Maintenance of a High Influenza Vaccination Rate and Improvement in Health Outcomes in a Pediatric Sickle Cell Disease Clinic. J Pediatr Hematol Oncol. 2022 Jan 01;44(1):e46-e50. doi: 10.1097/MPH.0000000000002192. PMID: 33974583; PMCID: PMC8581069.
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J Pediatr Hematol Oncol. 2022 Jan 01;44(1):e46-e50. doi: 10.1097/MPH.0000000000002192.

Maintenance of a High Influenza Vaccination Rate and Improvement in Health Outcomes in a Pediatric Sickle Cell Disease Clinic.

Journal of pediatric hematology/oncology

Zachary C Lo, Amy E Sobota

Affiliations

  1. Boston University School of Medicine.
  2. Department of Pediatrics, Boston Medical Center, Boston, MA.

PMID: 33974583 PMCID: PMC8581069 DOI: 10.1097/MPH.0000000000002192

Abstract

BACKGROUND: Children with sickle cell disease (SCD) are at high-risk of complications from influenza and should receive an influenza vaccination seasonally. Despite this recommendation, vaccination rates remain suboptimal. Boston Medical Center (BMC) previously achieved high influenza vaccination rates among its pediatric patients with SCD. The purpose of this study was to determine whether this high vaccination rate has been maintained and whether it has influenced outcome measures.

PATIENTS AND METHODS: A retrospective chart review was conducted in the hematology clinic at an urban, academic medical center. Fisher's exact test and the independent samples t test were used to determine if there were any significant differences in characteristics between patients with influenza and patients without influenza, as well as between vaccinated and unvaccinated patients. Influenza vaccination rate, influenza-related hospitalization rate, and influenza-positive rate were collected and compared with reported rates.

RESULTS: Data from 124 pediatric patients with SCD were examined. The influenza vaccination rate for pediatric patients with SCD at BMC (90.32%) was higher than previous studies that were not conducted at BMC, while BMC's influenza-related hospitalization rate (0) and influenza-positive rate (4.84%) were lower than other studies. Subjects who contracted influenza were younger than those who did not (4.67 vs. 10.03 y, P=0.005).

CONCLUSIONS: BMC has maintained a high influenza vaccination rate among pediatric patients with SCD. BMC's vaccination strategy has been successful at improving outcome measures including rates of influenza and influenza hospitalizations without requiring additional staff. Such efforts should be replicated at other centers.

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Conflict of interest statement

The authors declare no conflict of interest.

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