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Mirzapoiazova T, Xiao G, Mambetsariev B, et al. Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Mol Cancer Ther. 2021;20(10):1820-1835doi: 10.1158/1535-7163.MCT-21-0013.
Mirzapoiazova, T., Xiao, G., Mambetsariev, B., Nasser, M. W., Miaou, E., Singhal, S. S., Srivastava, S., Mambetsariev, I., Nelson, M. S., Nam, A., Behal, A., Atri, P., Muschen, M., Tissot, F. L. H., Miser, J., Kovach, J. S., Sattler, M., Batra, S. K., Kulkarni, P., & Salgia, R. (2021). Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Molecular cancer therapeutics, 20(10), 1820-1835. https://doi.org/10.1158/1535-7163.MCT-21-0013
Mirzapoiazova, Tamara, et al. "Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer." Molecular cancer therapeutics vol. 20,10 (2021): 1820-1835. doi: https://doi.org/10.1158/1535-7163.MCT-21-0013
Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Mol Cancer Ther. 2021 Oct;20(10):1820-1835. doi: 10.1158/1535-7163.MCT-21-0013. Epub 2021 Jul 12. PMID: 34253596; PMCID: PMC8722383.
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Mol Cancer Ther. 2021 Oct;20(10):1820-1835. doi: 10.1158/1535-7163.MCT-21-0013. Epub 2021 Jul 12.

Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.

Molecular cancer therapeutics

Tamara Mirzapoiazova, Gang Xiao, Bolot Mambetsariev, Mohd W Nasser, Emily Miaou, Sharad S Singhal, Saumya Srivastava, Isa Mambetsariev, Michael S Nelson, Arin Nam, Amita Behal, Pranita Atri, Markus Muschen, François L H Tissot, James Miser, John S Kovach, Martin Sattler, Surinder K Batra, Prakash Kulkarni, Ravi Salgia

Affiliations

  1. Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California.
  2. Department of Systems Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.
  3. Institute of Immunology, Institute of Hematology, Zhejiang University School of Medicine, Zhejiang, China.
  4. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.
  5. The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, California.
  6. The Light Microscopy and Digital Imaging Core, Beckman Research Institute, City of Hope, Duarte, California.
  7. Center of Molecular and Cellular Oncology, Yale University, New Haven, Connecticut.
  8. Department of Pediatrics, City of Hope National Medical Center, Duarte, California.
  9. Lixte Biotechnology Holdings, Inc., East Setauket, New York.
  10. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  11. Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California. [email protected].

PMID: 34253596 PMCID: PMC8722383 DOI: 10.1158/1535-7163.MCT-21-0013

Abstract

Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many cancers, including small cell lung cancer (SCLC). Here we report that LB100, a small molecule inhibitor of PP2A, when combined with platinum-based chemotherapy, synergistically elicited an antitumor response both

©2021 The Authors; Published by the American Association for Cancer Research.

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