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Lovell-Badge R, Anthony E, Barker RA, et al. ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update. Stem Cell Reports. 2021;16(6):1398-1408doi: 10.1016/j.stemcr.2021.05.012.
Lovell-Badge, R., Anthony, E., Barker, R. A., Bubela, T., Brivanlou, A. H., Carpenter, M., Charo, R. A., Clark, A., Clayton, E., Cong, Y., Daley, G. Q., Fu, J., Fujita, M., Greenfield, A., Goldman, S. A., Hill, L., Hyun, I., Isasi, R., Kahn, J., Kato, K., Kim, J. S., Kimmelman, J., Knoblich, J. A., Mathews, D., Montserrat, N., Mosher, J., Munsie, M., Nakauchi, H., Naldini, L., Naughton, G., Niakan, K., Ogbogu, U., Pedersen, R., Rivron, N., Rooke, H., Rossant, J., Round, J., Saitou, M., Sipp, D., Steffann, J., Sugarman, J., Surani, A., Takahashi, J., Tang, F., Turner, L., Zettler, P. J., & Zhai, X. (2021). ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update. Stem cell reports, 16(6), 1398-1408. https://doi.org/10.1016/j.stemcr.2021.05.012
Lovell-Badge, Robin, et al. "ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update." Stem cell reports vol. 16,6 (2021): 1398-1408. doi: https://doi.org/10.1016/j.stemcr.2021.05.012
Lovell-Badge R, Anthony E, Barker RA, Bubela T, Brivanlou AH, Carpenter M, Charo RA, Clark A, Clayton E, Cong Y, Daley GQ, Fu J, Fujita M, Greenfield A, Goldman SA, Hill L, Hyun I, Isasi R, Kahn J, Kato K, Kim JS, Kimmelman J, Knoblich JA, Mathews D, Montserrat N, Mosher J, Munsie M, Nakauchi H, Naldini L, Naughton G, Niakan K, Ogbogu U, Pedersen R, Rivron N, Rooke H, Rossant J, Round J, Saitou M, Sipp D, Steffann J, Sugarman J, Surani A, Takahashi J, Tang F, Turner L, Zettler PJ, Zhai X. ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update. Stem Cell Reports. 2021 Jun 08;16(6):1398-1408. doi: 10.1016/j.stemcr.2021.05.012. Epub 2021 May 27. PMID: 34048692; PMCID: PMC8190668.
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Stem Cell Reports. 2021 Jun 08;16(6):1398-1408. doi: 10.1016/j.stemcr.2021.05.012. Epub 2021 May 27.

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

Stem cell reports

Robin Lovell-Badge, Eric Anthony, Roger A Barker, Tania Bubela, Ali H Brivanlou, Melissa Carpenter, R Alta Charo, Amander Clark, Ellen Clayton, Yali Cong, George Q Daley, Jianping Fu, Misao Fujita, Andy Greenfield, Steve A Goldman, Lori Hill, Insoo Hyun, Rosario Isasi, Jeffrey Kahn, Kazuto Kato, Jin-Soo Kim, Jonathan Kimmelman, Jürgen A Knoblich, Debra Mathews, Nuria Montserrat, Jack Mosher, Megan Munsie, Hiromitsu Nakauchi, Luigi Naldini, Gail Naughton, Kathy Niakan, Ubaka Ogbogu, Roger Pedersen, Nicolas Rivron, Heather Rooke, Janet Rossant, Jeff Round, Mitinori Saitou, Douglas Sipp, Julie Steffann, Jeremy Sugarman, Azim Surani, Jun Takahashi, Fuchou Tang, Leigh Turner, Patricia J Zettler, Xiaomei Zhai

Affiliations

  1. Francis Crick Institute, London, UK. Electronic address: [email protected].
  2. International Society for Stem Cell Research, Skokie, IL, USA.
  3. Cambridge Center for Brain Repair and WT-MRC Stem Cell Institute, Cambridge, UK.
  4. Simon Fraser University, Burnaby, BC, Canada.
  5. The Rockefeller University, New York, NY, USA.
  6. ElevateBio/Carpenter Group Consulting, Waltham, MA, USA.
  7. University of Wisconsin-Madison, Madison, WI, USA.
  8. University of California, Los Angeles, Los Angeles, CA, USA.
  9. Vanderbilt University, Nashville, TN, USA.
  10. Peking University, Beijing, China.
  11. Harvard Medical School, Boston, MA, USA.
  12. University of Michigan, Ann Arbor, MI USA.
  13. Kyoto University, Kyoto, Japan.
  14. MRC Harwell Institute, Oxfordshire, UK.
  15. University of Rochester Medical Center, Rochester, NY, USA; University of Copenhagen, Copenhagen, Denmark.
  16. MD Anderson, Houston, TX, USA.
  17. Harvard Medical School, Boston, MA, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  18. University of Miami, Coral Gables, FL, USA.
  19. Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
  20. Osaka University, Suita, Japan.
  21. Seoul National University, Seoul, Korea.
  22. McGill University, Montreal, QC, Canada.
  23. IMBA-Institute of Molecular Biotechnology, Vienna, Austria.
  24. Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain.
  25. University of Melbourne, Melbourne, VIC, Australia.
  26. Stanford University, Stanford, CA, USA; University of Tokyo, Tokyo, Japan.
  27. Università Vita-Salute San Raffaele, Milan, Italy.
  28. Histogen, San Diego, CA, USA.
  29. Francis Crick Institute, London, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
  30. University of Alberta, Edmonton, AB, Canada.
  31. Stanford University, Stanford, CA, USA.
  32. Broad Institute, Cambridge, MA, USA.
  33. Gairdner Foundation/SickKids, Toronto, ON, Canada.
  34. Institute of Health Economics, Edmonton, AB, Canada.
  35. RIKEN Center for Developmental Biology, Wako, Japan; Keio University School of Medicine, Tokyo, Japan.
  36. Université Paris Descartes, Paris, France.
  37. Gurdon Institute, University of Cambridge, Cambridge, UK.
  38. University of Minnesota, Minneapolis, MN, USA.
  39. Ohio State University, Columbus, OH, USA.
  40. Peking Union Medical College, Beijing, China.

PMID: 34048692 PMCID: PMC8190668 DOI: 10.1016/j.stemcr.2021.05.012

Abstract

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here.

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Conflict of interest statement

Declaration of interests R.L.-B. has no financial conflicts to declare. R.L.-B. serves on the following advisory boards: Scientific and Clinical Advances Advisory Committee of the Human Fertility and

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