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Dees WL, Hiney JK, Srivastava VK. IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty. Neuroendocrinology. 2021;111(12):1151-1163doi: 10.1159/000514217.
Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2021). IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty. Neuroendocrinology, 111(12), 1151-1163. https://doi.org/10.1159/000514217
Dees, William L, et al. "IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty." Neuroendocrinology vol. 111,12 (2021): 1151-1163. doi: https://doi.org/10.1159/000514217
Dees WL, Hiney JK, Srivastava VK. IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty. Neuroendocrinology. 2021;111(12):1151-1163. doi: 10.1159/000514217. Epub 2021 Jan 06. PMID: 33406521; PMCID: PMC8257778.
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Neuroendocrinology. 2021;111(12):1151-1163. doi: 10.1159/000514217. Epub 2021 Jan 06.

IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty.

Neuroendocrinology

William L Dees, Jill K Hiney, Vinod K Srivastava

Affiliations

  1. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA, [email protected].
  2. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA.

PMID: 33406521 PMCID: PMC8257778 DOI: 10.1159/000514217

Abstract

The pubertal process is initiated as a result of complex neuroendocrine interactions within the preoptic and hypothalamic regions of the brain. These interactions ultimately result in a timely increase in the secretion of gonadotropin-releasing hormone (GnRH). Researchers for years have believed that this increase is due to a diminished inhibitory tone which has applied a prepubertal brake on GnRH secretion, as well as to the gradual development of excitatory inputs driving the increased release of the peptide. Over the years, insulin-like growth factor-1 (IGF-1) has emerged as a prime candidate for playing an important role in the onset of puberty. This review will first present initial research demonstrating that IGF-1 increases in circulation as puberty approaches, is able to induce the release of prepubertal GnRH, and can advance the timing of puberty. More recent findings depict an early action of IGF-1 to activate a pathway that releases the inhibitory brake on prepubertal GnRH secretion provided by dynorphin, as well as demonstrating that IGF-1 can also act later in the process to regulate the synthesis and release of kisspeptin, a potent stimulator of GnRH at puberty.

© 2021 S. Karger AG, Basel.

Keywords: Gonadotropin-releasing hormone; Insulin-like growth factor-1; Neurokinin B; Puberty

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