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Zhou R, Yu J, Gu Z, et al. Microneedle-mediated therapy for cardiovascular diseases. Drug Deliv Transl Res. 2021;12(2):472-483doi: 10.1007/s13346-021-01073-7.
Zhou, R., Yu, J., Gu, Z., & Zhang, Y. (2022). Microneedle-mediated therapy for cardiovascular diseases. Drug delivery and translational research, 12(2), 472-483. https://doi.org/10.1007/s13346-021-01073-7
Zhou, Ruyi, et al. "Microneedle-mediated therapy for cardiovascular diseases." Drug delivery and translational research vol. 12,2 (2022): 472-483. doi: https://doi.org/10.1007/s13346-021-01073-7
Zhou R, Yu J, Gu Z, Zhang Y. Microneedle-mediated therapy for cardiovascular diseases. Drug Deliv Transl Res. 2022 Feb;12(2):472-483. doi: 10.1007/s13346-021-01073-7. Epub 2021 Oct 12. PMID: 34637115.
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Drug Deliv Transl Res. 2022 Feb;12(2):472-483. doi: 10.1007/s13346-021-01073-7. Epub 2021 Oct 12.

Microneedle-mediated therapy for cardiovascular diseases.

Drug delivery and translational research

Ruyi Zhou, Jicheng Yu, Zhen Gu, Yuqi Zhang

Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
  2. Zenomics Inc., Los Angeles, CA, 90095, USA.
  3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. [email protected].
  4. Department of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China. [email protected].
  5. Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 311121, China. [email protected].
  6. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China. [email protected].
  7. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. [email protected].
  8. Department of Burns and Wound Center, College of Medicine, Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, China. [email protected].

PMID: 34637115 DOI: 10.1007/s13346-021-01073-7

Abstract

Cardiovascular diseases remain a leading cause of global disease burden. To date, the limited drug delivery efficacy confines the therapeutic effect in most conventional approaches, such as intramyocardial injections and vascular devices, due to short-term drug release and low retention within the disease sites. As a typical transdermal medical device with a minimally invasive manner and controlled/sustained drug release pattern, microneedles have gained momentum in the field of cardiovascular therapy, from which several cardiovascular diseases have been benefited to the ultimate therapeutic effects. In this concise review, strategies based on the microneedles for the treatments of cardiovascular diseases are introduced, mainly focus on hypertension, atherosclerosis, thrombus, and myocardial diseases. The limitations at the present stage and perspectives of the next-generation microneedles for cardiovascular therapy are also discussed.

© 2021. Controlled Release Society.

Keywords: Biomaterials; Biomedical devices; Cardiovascular diseases; Drug delivery; Microneedles

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