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Bakre S, Holt SK, Oerline M, et al. Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes. Neurourol Urodyn. 2021;41(1):323-331doi: 10.1002/nau.24823.
Bakre, S., Holt, S. K., Oerline, M., Braffett, B. H., Pop-Busui, R., Wessells, H., Sarma, A. V. (2022). Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes. Neurourology and urodynamics, 41(1), 323-331. https://doi.org/10.1002/nau.24823
Bakre, Shivani, et al. "Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes." Neurourology and urodynamics vol. 41,1 (2022): 323-331. doi: https://doi.org/10.1002/nau.24823
Bakre S, Holt SK, Oerline M, Braffett BH, Pop-Busui R, Wessells H, Sarma AV. Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes. Neurourol Urodyn. 2022 Jan;41(1):323-331. doi: 10.1002/nau.24823. Epub 2021 Oct 21. PMID: 34672384.
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Neurourol Urodyn. 2022 Jan;41(1):323-331. doi: 10.1002/nau.24823. Epub 2021 Oct 21.

Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes.

Neurourology and urodynamics

Shivani Bakre, Sarah K Holt, Mary Oerline, Barbara H Braffett, Rodica Pop-Busui, Hunter Wessells, Aruna V Sarma,

Affiliations

  1. Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.
  2. Department of Urology and Diabetes Research Center, University of Washington, Seattle, Washington, USA.
  3. Biostatistics Center, George Washington University, Rockville, Maryland, USA.
  4. Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.

PMID: 34672384 DOI: 10.1002/nau.24823

Abstract

AIMS: Urinary incontinence (UI) in women is a dynamic condition with numerous risk factors yet most studies have focused on examining its prevalence at a single time. The objective of this study was to describe the long-term time course of UI in women with type 1 diabetes (T1D).

METHODS: Longitudinal data in women with T1D were collected from 568 women in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. Over a 12-year period, participants annually responded to whether they had experienced UI in the past year.

RESULTS: We identified four categories of UI in this population over time: 205 (36.1%) women never reported UI (no UI), 70 (12.3%) reported it one or two consecutive years only (isolated UI), 247 (43.5%) periodically changed status between UI and no UI (intermittent UI), and 46 (8.1%) reported UI continuously after the first report (persistent UI). Compared to women reporting no/isolated UI, women displaying the intermittent phenotype were significantly more likely to be obese (OR: 1.86, 95% CI 1.15, 3.00) and report prior hysterectomy (OR: 2.57, 95% CI: 1.39, 4.77); whereas women with persistent UI were significantly more likely to have abnormal autonomic function (OR: 2.36, 95% CI: 1.16-4.80).

CONCLUSIONS: UI is a dynamic condition in women with T1D. Varying risk factors observed for the different phenotypes of UI suggest distinctive pathophysiological mechanisms. These findings have the potential to be used to guide individualized interventions for UI in women with diabetes.

© 2021 Wiley Periodicals LLC.

Keywords: natural history; type 1 diabetes; urinary incontinence

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