J Viral Hepat. 2022 Jan;29(1):4-20. doi: 10.1111/jvh.13590. Epub 2021 Aug 12.
COVID-19 and the Liver: Lessons Learnt from the EAST and the WEST, A Year Later.
Journal of viral hepatitis
Sirina Ekpanyapong, Chalermrat Bunchorntavakul, K Rajender Reddy
Affiliations
Affiliations
- Division of Gastroenterology and Hepatology, Department of Medicine, Rajavithi Hospital, Bangkok, Thailand.
- Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
PMID: 34352133
PMCID: PMC8446947 DOI: 10.1111/jvh.13590
Abstract
Globally, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) has been a major cause for significant morbidity and mortality. Since the start of the pandemic, several hepato-biliary manifestations in coronavirus disease 2019 (COVID-19) have been described and unique considerations raised. The review aims to summarize the pathogenesis and hepato-biliary manifestations in COVID-19 and discuss the similarities, contrasting features and disease-specific management across a range of hepato-biliary diseases from the EAST and the WEST. Published studies and regional society guidelines from the EAST and the WEST were comprehensively reviewed and summarized. A wide range of hepato-biliary manifestations, including the infrequent and chronic manifestation of cholangiopathy, has been observed in COVID-19. The pathogenesis of liver injury is multifactorial and with scant evidence for a direct SARS-CoV-2 infection of the liver. Patients with non-alcoholic fatty liver disease, cirrhosis, and liver cancer are potentially at increased risk for severe COVID-19, and there are unique considerations in chronic hepatitis B or C, hepatocellular carcinoma, and in those immunosuppressed such as autoimmune hepatitis or liver transplant recipients. With the surges in SARS-CoV-2 infection, liver transplant activity has variably been impacted. Preliminarily, SARS-CoV-2 vaccines appear to be safe in those with chronic liver disease and in transplant recipients, while emerging data suggest the need for a third dose in immunosuppressed patients. In conclusion, patients with chronic liver disease, particularly cirrhosis, and liver transplant recipients, are vulnerable to severe COVID-19. Over the past year, several unique considerations have been highlighted across a spectrum of hepato-biliary diseases. Vaccination is strongly recommended for those with chronic liver disease and liver transplant recipients.
© 2021 John Wiley & Sons Ltd.
Keywords: COVID-19; cirrhosis; hepatitis; liver transplant; vaccination
References
- Fix OK, Hameed B, Fontana RJ, et al. Clinical best practice advice for hepatology and liver transplant providers during the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement. Hepatology. 2020;72(1):287-304. - PubMed
- Zhang C, Shi L, Wang F-S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020;5(5):428-430. - PubMed
- Ji D, Zhang D, Yang T, et al. Effect of COVID-19 on patients with compensated chronic liver diseases. Hepatol Int. 2020;14(5):701-710. - PubMed
- Qiu H, Wander P, Bernstein D, Satapathy SK. Acute on chronic liver failure from novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Liver Int. 2020;40(7):1590-1593. - PubMed
- Iavarone M, D'Ambrosio R, Soria A, et al. High rates of 30-day mortality in patients with cirrhosis and COVID-19. J Hepatol. 2020;73(5):1063-1071. - PubMed
- Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M. COVID-19 and the liver. J Hepatol. 2020;73(5):1231-1240. - PubMed
- Li Y, Xiao S-Y. Hepatic involvement in COVID-19 patients: Pathology, pathogenesis, and clinical implications. J Med Virol. 2020;92(9):1491-1494. - PubMed
- Case fatality rate of the ongoing COVID-19 pandemic. Accessed November 14, 2020. https://ourworldindata.org/mortality-risk-covid - PubMed
- WHO Coronavirus Disease (COVID-19) Dashboard Accessed June 12, 2021. https://covid19.who.int/?gclid=EAIaIQobChMIqqrtlK2C7QIVGxwrCh3LcQm2EAAYASAAEgKaefD_BwE - PubMed
- Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(10223):507-513. - PubMed
- Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. - PubMed
- Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. - PubMed
- Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20(4):425-434. - PubMed
- Xu X-W, Wu X-X, Jiang X-G, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ (Clin Res). 2020;368:m606. - PubMed
- Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Resp Med. 2020;8(5):475-481. - PubMed
- Cai Q, Huang D, Ou P, et al. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020;75(7):1742-1752. - PubMed
- Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382(19):1787-1799. - PubMed
- Fan Z, Chen L, Li J, et al. Clinical features of covid-19-related liver functional abnormality. Clin Gastroenterol Hepatol. 2020;18(7):1561-1566. - PubMed
- Fan Z, Chen L, Li J, et al. Clinical features of COVID-19 related liver damage. medRxiv. https://doi.org/10.1101/2020.02.26.20026971 - PubMed
- Huang Y, Yang R, Xu Y, Gong P. Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China. medRxiv. https://doi.org/10.1101/2020.02.27.20029009 - PubMed
- Cao M, Zhang D, Wang Y, et al. Clinical features of patients infected with the 2019 novel coronavirus (COVID-19) in Shanghai, China. medRxiv. https://doi.org/10.1101/2020.03.04.20030395 - PubMed
- Cai Q, Huang D, Yu H, et al. COVID-19: Abnormal liver function tests. J Hepatol. 2020;73(3):566-574. - PubMed
- Zhang Y, Zheng L, Liu L, Zhao M, Xiao J, Zhao Q. Liver impairment in COVID-19 patients: A retrospective analysis of 115 cases from a single centre in Wuhan city, China. Liver Int. 2020;40(9):2095-2103. - PubMed
- Vespa E, Pugliese N, Piovani D, et al. Liver tests abnormalities in COVID-19: trick or treat? J Hepatol. 2020;73(5):1275-1276. - PubMed
- Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected With SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-1581. - PubMed
- Cholankeril G, Podboy A, Aivaliotis VI, et al. High prevalence of concurrent gastrointestinal manifestations in patients with severe acute respiratory syndrome coronavirus 2: Early experience From California. Gastroenterology. 2020;159(2):775-777. - PubMed
- Arentz M, Yim E, Klaff L, et al. Characteristics and outcomes of 21 critically Ill patients With COVID-19 in Washington State. JAMA. 2020;323(16):1612-1614. - PubMed
- Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-2059. - PubMed
- Tang C, Zhang K, Wang W, et al. Clinical characteristics of 20,662 patients with COVID-19 in mainland China: A systemic review and meta-analysis. medRxiv. https://doi.org/10.1101/2020.04.18.20070565 - PubMed
- Ji D, Qin E, Xu J, et al. Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study. J Hepatol. 2020;73(2):451-453. - PubMed
- Chai X, Hu L, Zhang Y, et al. Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv. https://doi.org/10.1101/2020.02.03.931766 - PubMed
- Clinical best practice advice for hepatology and liver transplant providers during the covid-19 pandemic: AASLD expert panel consensus statement (Released: June 25, 2020). https://www.aasld.org/sites/default/files/2020-06/AASLD-COVID19-ExpertPanelConsensusStatement-June252020-v2-FINAL.pdf - PubMed
- Lei F, Liu YM, Zhou F, et al. Longitudinal association between markers of liver injury and mortality in COVID-19 in China. Hepatology. 2020;72(2):389-398. - PubMed
- Liu W, Tao ZW, Wang L, et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J. 2020;133(9):1032-1038. - PubMed
- Pereira MR, Mohan S, Cohen DJ, et al. COVID-19 in solid organ transplant recipients: Initial report from the US epicenter. Am J Transplant. 2020;20(7):1800-1808. - PubMed
- Xu L, Liu J, Lu M, Yang D, Zheng X. Liver injury during highly pathogenic human coronavirus infections. Liver Int. 2020;40(5):998-1004. - PubMed
- Qi X, Liu C, Jiang Z, et al. Multicenter analysis of clinical characteristics and outcomes in patients with COVID-19 who develop liver injury. J Hepatol. 2020;73(2):455-458. - PubMed
- Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663-1665. - PubMed
- Clinical insights for hepatology and liver transplant providers during the COVID-19 pandemic (Released: April 7, 2020). https://www.aasld.org/sites/default/files/2020-04/AASLD-COVID19-ClinicalInsights-4.07.2020-Final.pdf - PubMed
- Major Updates to COVID-19 Clinical Insights Document (Released April 16, 2020). https://www.aasld.org/sites/default/files/2020-04/COVID19-ClinicalInsightsUpdates-4162020.pdf - PubMed
- Albillos A, Lario M, Álvarez-Mon M. Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. J Hepatol. 2014;61(6):1385-1396. - PubMed
- Boettler T, Marjot T, Newsome PN, et al. Impact of COVID-19 on the care of patients with liver disease: EASL-ESCMID position paper after 6 months of the pandemic. JHEP Reports. 2020;2(5):100169. - PubMed
- Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Cholangiocyte pathobiology. Nat Rev Gastroenterol Hepatol. 2019;16(5):269-281. - PubMed
- Tian S, Xiong Y, Liu H, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol. 2020;33(6):1007-1014. https://doi.org/10.1038/s41379-020-0536-x - PubMed
- Gordon DE, Jang GM, Bouhaddou M, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020;583(7816):459-468. - PubMed
- Schaefer EAK, Arvind A, Bloom PP, Chung RT. Interrelationship between coronavirus infection and liver disease. Clin Liv Dis. 2020;15(5):175-180. - PubMed
- Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. 2020;382(24):2327-2336. - PubMed
- Li J, Fan J-G. Characteristics and mechanism of liver injury in 2019 coronavirus disease. J Clin Transl Hepatol. 2020;8(1):13-17. - PubMed
- Surveillance Epidemiology of Coronavirus (COVID-19) Under Research Exclusion (SECURE)-CIRRHOSIS Registry, Updates and Data. Accessed May 7, 2021. https://covidcirrhosis.web.unc.edu/updates-and-data/ - PubMed
- COVID-19 in Patients with Liver Disease or Transplantation (COVID-Hep) Registry. Accessed May 7, 2021. https://www.covid-hep.net/img/update_20200825.pdf - PubMed
- Weisberg IS, Jacobson IM. Cardiovascular diseases and the liver. Clin Liver Dis. 2011;15(1):1-20. - PubMed
- Faruqui S, Okoli FC, Olsen SK, et al. Cholangiopathy after severe COVID-19: clinical features and prognostic implications. Am J Gastroenterol. 2021;116(7):1414-1425. - PubMed
- Roth NC, Kim A, Vitkovski T, et al. Post-COVID-19 cholangiopathy: a novel entity. Am J Gastroenterol. 2021;116(5):1077-1082. - PubMed
- Lippi G, de Oliveira MHS, Henry BM. Chronic liver disease is not associated with severity or mortality in Coronavirus disease 2019 (COVID-19): a pooled analysis. Eur J Gastro Hepatol. 2021;33(1):114-115. - PubMed
- Williamson E, Walker AJ, Bhaskaran KJ, et al. OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients. medRxiv. https://doi.org/10.1101/2020.05.06.20092999 - PubMed
- Singh S, Khan A. Clinical characteristics and outcomes of coronavirus disease 2019 among patients with preexisting liver disease in the United States: A Multicenter Research Network Study. Gastroenterology. 2020;159(2):768-771.e763. - PubMed
- Marjot T, Moon AM, Cook JA, et al. Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study. J Hepatol. 2021;74(3):567-577. - PubMed
- Zhang B, Huang W, Zhang S. Clinical features and outcomes of Coronavirus Disease 2019 (COVID-19) patients with chronic hepatitis B virus infection. Clin Gastroenterol Hepatol. 2020;18(11):2633-2637. - PubMed
- Blach S, Kondili LA, Aghemo A, et al. Impact of COVID-19 on global HCV elimination efforts. J Hepatol. 2021;74(1):31-36. - PubMed
- Lau G, Sharma M. Clinical practice guidance for hepatology and liver transplant providers during the COVID-19 pandemic: APASL expert panel consensus recommendations. Hep Intl. 2020;1-14. - PubMed
- Di Giorgio A, Nicastro E, Speziani C, et al. Health status of patients with autoimmune liver disease during SARS-CoV-2 outbreak in northern Italy. J Hepatol. 2020;73(3):702-705. - PubMed
- Gerussi A, Rigamonti C, Elia C, et al. Coronavirus Disease 2019 in autoimmune hepatitis: a lesson from immunosuppressed patients. Hepatol Commun. 2020;4(9):1257-1262. - PubMed
- Boettler T, Newsome PN, Mondelli MU, et al. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper. JHEP Rep. 2020;2(3):100113. - PubMed
- Targher G, Mantovani A, Byrne CD, et al. Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores. Gut. 2020;69(8):1545-1547. - PubMed
- Hashemi N, Viveiros K, Redd WD, et al. Impact of chronic liver disease on outcomes of hospitalized patients with COVID-19: A multicentre United States experience. Liver Int. 2020;40(10):2515-2521. - PubMed
- Shalimar EA, Vaishnav M, et al. Poor outcomes in patients with cirrhosis and Corona Virus Disease-19. Indian J Gastroenterol. 2020;39(3):285-291. - PubMed
- Bajaj JS, Garcia-Tsao G, Biggins SW, et al. Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort. Gut. 2021;70(3):531-536. https://doi.org/10.1136/gutjnl-2020-322118 - PubMed
- Liu H, He X, Wang Y, et al. Management of COVID-19 in patients after liver transplantation: Beijing working party for liver transplantation. Hep Intl. 2020;14(4):432-436. - PubMed
- Qin J, Wang H, Qin X, et al. Perioperative presentation of COVID-19 disease in a liver transplant recipient. Hepatology. 2020;72(4):1491-1493. - PubMed
- D’Antiga L. Coronaviruses and immunosuppressed patients: The facts during the third epidemic. Liver Transpl. 2020;26(6):832-834. - PubMed
- Rodriguez-Peralvarez M, Salcedo M, Colmenero J, Pons JA. Modulating immunosuppression in liver transplant patients with COVID-19. Gut. 2021;70(7):1412-1414. - PubMed
- Becchetti C, Zambelli MF, Pasulo L, et al. COVID-19 in an international European liver transplant recipient cohort. Gut. 2020;69(10):1832-1840. - PubMed
- Colmenero J, Rodriguez-Peralvarez M, Salcedo M, et al. Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients. J Hepatol. 2021;74(1):148-155. - PubMed
- Webb GJ, Marjot T, Cook JA, et al. Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study. The Lancet Gastroenterology & Hepatology. 2020;5(11):1008-1016. - PubMed
- Ravanan R, Callaghan CJ, Mumford L, et al. SARS-CoV-2 infection and early mortality of waitlisted and solid organ transplant recipients in England: A national cohort study. Am J Transplant. 2020;20(11):3008-3018. - PubMed
- Lee BT, Perumalswami PV, Im GY, et al. COVID-19 in liver transplant recipients: an initial experience From the US epicenter. Gastroenterology. 2020;159(3):1176-1178 e1172. - PubMed
- Belli LS, Duvoux C, Karam V, et al. COVID-19 in liver transplant recipients: preliminary data from the ELITA/ELTR registry. Lancet Gastroenterol Hepatol. 2020;5(8):724-725. - PubMed
- Polak WG, Fondevila C, Karam V, et al. Impact of COVID-19 on liver transplantation in Europe: alert from an early survey of European Liver and Intestine Transplantation Association and European Liver Transplant Registry. Transpl Int. 2020;33(10):1244-1252. - PubMed
- Liang W, Guan W, Chen R, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335-337. - PubMed
- Lee LYW, Cazier J-B, Angelis V, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. The Lancet. 2020;395(10241):1919-1926. - PubMed
- Yu J, Ouyang W, Chua MLK, Xie C. SARS-CoV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China. JAMA Oncol. 2020;6(7):1108-1110. - PubMed
- Zhang L, Zhu F, Xie L, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol. 2020;31(7):894-901. - PubMed
- Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. - PubMed
- Mehta V, Goel S, Kabarriti R, et al. Case fatality rate of cancer patients with COVID-19 in a New York Hospital System. Cancer Discov. 2020;10(7):935-941. - PubMed
- Kudo M, Kurosaki M, Ikeda M, et al. Treatment of hepatocellular carcinoma during the COVID-19 outbreak: The Working Group report of JAMTT-HCC. Hepatol Res. 2020;50(9):1004-1014. - PubMed
- Chan SL, Kudo M. Impacts of COVID-19 on liver cancers: during and after the pandemic. Liver Cancer. 2020;9(5):491-502. - PubMed
- Amaddeo G, Brustia R, Allaire M, et al. Impact of COVID-19 on the management of hepatocellular carcinoma in a high-prevalence area. JHEP Rep. 2021;3(1):100199. - PubMed
- Iavarone M, Sangiovanni A, Carrafiello G, Rossi G, Lampertico P. Management of hepatocellular carcinoma in the time of COVID-19. Ann Oncol. 2020;31(8):1084-1085. - PubMed
- Loupy A, Aubert O, Reese PP, Bastien O, Bayer F, Jacquelinet C. Organ procurement and transplantation during the COVID-19 pandemic. The Lancet. 2020;395(10237):e95-e96. - PubMed
- de Vries APJ, Alwayn IPJ, Hoek RAS, et al. Immediate impact of COVID-19 on transplant activity in the Netherlands. Transpl Immunol. 2020;61:101304. - PubMed
- Gruttadauria S. Preliminary analysis of the impact of the coronavirus disease 2019 outbreak on Italian liver transplant programs. Liver Transpl. 2020;26(7):941-944. - PubMed
- Maggi U, De Carlis L, Yiu D, et al. The impact of the COVID-19 outbreak on liver transplantation programs in Northern Italy. Am J Transplant. 2020;20(7):1840-1848. - PubMed
- Thorburn D, Taylor R, Whitney J, et al. Resuming liver transplantation amid the COVID-19 pandemic. Lancet Gastroenterol Hepatol. 2021;6(1):12-13. - PubMed
- Pathanki AM, Mirza DF. Liver transplantation during the times of COVID-19 - viruses, vaccines and beyond. J Clin Exp Hepatol. 2021;11(4):411-413. https://doi.org/10.1016/j.jceh.2021.1004.1014 - PubMed
- Pahari H, Shellagi N, Nath B. Deceased donor liver transplantation in India in the COVID-19 Era: current scenario and future perspectives. Transpl Proc. 2020;52(9):2684-2687. - PubMed
- De Carlis R, Vella I, Incarbone N, et al. Impact of the COVID-19 pandemic on liver donation and transplantation: A review of the literature. World J Gastroenterol. 2021;27(10):928-938. - PubMed
- Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-2615. - PubMed
- Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-416. - PubMed
- Zhang Y, Zeng G, Pan H, et al. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. Lancet Infect Dis. 2021;21(2):181-192. - PubMed
- Aggeletopoulou I, Davoulou P, Konstantakis C, Thomopoulos K, Triantos C. Response to hepatitis B vaccination in patients with liver cirrhosis. Rev Med Virol. 2017;27(6):e1942. - PubMed
- Duchini A, Hendry RM, Nyberg LM, Viernes ME, Pockros PJ. Immune response to influenza vaccine in adult liver transplant recipients. Liver Transpl. 2001;7(4):311-313. - PubMed
- McCashland TM, Preheim LC, Gentry MJ. Pneumococcal vaccine response in cirrhosis and liver transplantation. J Infect Dis. 2000;181(2):757-760. - PubMed
- Ou MT, Boyarsky BJ, Motter JD, et al. Safety and reactogenicity of 2 doses of SARS-CoV-2 vaccination in solid organ transplant recipients. Transplantation. 2021. Ahead of Print. - PubMed
- Boyarsky BJ, Werbel WA, Avery RK, et al. Immunogenicity of a single dose of SARS-CoV-2 messenger RNA vaccine in solid organ transplant recipients. JAMA. 2021;325(17):1784-1786. - PubMed
- Boyarsky BJ, Werbel WA, Avery RK, et al. Antibody response to 2-Dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325(21):2204-2206. - PubMed
- Kamar N, Abravanel F, Marion O, Couat C, Izopet J, Del Bello A. Three doses of an mRNA Covid-19 vaccine in solid-organ transplant recipients. N Engl J Med. 2021. - PubMed
- Fu Y, Zhu R, Bai T, et al. Clinical features of patients infected with coronavirus disease 2019 with elevated liver biochemistries: A multicenter, retrospective study. Hepatology. 2021;73(4):1509-1520. - PubMed
- Wang Y, Liu S, Liu H, et al. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol. 2020;73(4):807-816. - PubMed
- Huang R, Zhu L, Wang J, et al. Clinical features of patients with COVID-19 patients with nonalcoholic fatty liver disease. Hepatol Commun. 2020;4(12):1758-1768. https://doi.org/10.1002/hep4.1592. - PubMed
- Zhou YJ, Zheng KI, Wang XB, et al. Younger patients with MAFLD are at increased risk of severe COVID-19 illness: A multicenter preliminary analysis. J Hepatol. 2020;73(3):719-721. - PubMed
- Yadav DK, Singh A, Zhang Q, et al. Involvement of liver in COVID-19: systematic review and meta-analysis. Gut. 2021;70(4):807-809. - PubMed
- Dhampalwar S, Saigal S, Choudhary N, et al. Outcomes of coronavirus disease 2019 in living donor liver transplant recipients. Liver Transpl. 2020;26(12):1665-1666. - PubMed
- Sarin SK, Choudhury A, Lau GK, et al. Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study). Hep Intl. 2020;14(5):690-700. - PubMed
- Phipps MM, Barraza LH, LaSota ED, et al. Acute Liver Injury in COVID-19: prevalence and association with clinical outcomes in a large U.S. Cohort. Hepatology. 2020;72(3):807-817. - PubMed
- Hundt MA, Deng Y, Ciarleglio MM, Nathanson MH, Lim JK. Abnormal liver tests in COVID-19: A retrospective observational cohort study of 1,827 Patients in a major U.S. Hospital Network. Hepatology. 2020;72(4):1169-1176. - PubMed
- Bloom PP, Meyerowitz EA, Reinus Z, et al. Liver biochemistries in hospitalized patients With COVID-19. Hepatology. 2021;73(3):890-900. - PubMed
- Clift AK, Coupland CAC, Keogh RH, et al. Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ (Clin Res ed). 2020;371:m3731. - PubMed
- Rabiee A, Sadowski B, Adeniji N, et al. Liver Injury in Liver transplant recipients with coronavirus disease 2019 (COVID-19): U.S. multicenter experience. Hepatology. 2020;72(6):1900-1911. - PubMed
- Kates OS, Haydel BM, Florman SS, et al. COVID-19 in solid organ transplant: a multi-center cohort study. Clin Infect Dis. 2020;ciaa1097. https://doi.org/10.1093/cid/ciaa1097 - PubMed
- Belli LS, Fondevila C, Cortesi PA, et al. Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA/ELTR Multi-center European Study. Gastroenterology. 2021;160(4):1151-1163 e1153. - PubMed
- Verhelst X, Somers N, Geerts A, Degroote H, Van Vlierberghe H. Health status of patients with autoimmune hepatitis is not affected by the SARS-CoV-2 outbreak in Flanders, Belgium. J Hepatol. 2021;74(1):240-241. - PubMed
- Butt AA, Yan P, Chotani RA, Shaikh OS. Mortality is not increased in SARS-CoV-2 infected persons with hepatitis C virus infection. Liver Int. 2021;41(8):1824-1831. - PubMed
- Kim D, Adeniji N, Latt N, et al. Predictors of outcomes of COVID-19 in patients with chronic liver disease: US Multi-center Study. Clin Gastroenterol Hepatol. 2021;19(7):1469-1479. - PubMed
- Chen X, Jiang Q, Ma Z, et al. Clinical characteristics of hospitalized patients with SARS-CoV-2 and hepatitis B virus Co-infection. medRxiv. 2020;35(6):842-845. - PubMed
- Zha L, Li S, Pan L, et al. Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). Med J Aust. 2020;212(9):416-420. - PubMed
- Sachdeva S, Khandait H, Kopel J, Aloysius MM, Desai R, Goyal H. NAFLD and COVID-19: a pooled analysis. SN Compr Clin Med. 2020;1-4. - PubMed
- Forlano R, Mullish BH, Mukherjee SK, et al. In-hospital mortality is associated with inflammatory response in NAFLD patients admitted for COVID-19. PLoS One. 2020;15(10):e0240400. - PubMed
- Mahamid M, Nseir W, Khoury T, et al. Nonalcoholic fatty liver disease is associated with COVID-19 severity independently of metabolic syndrome: a retrospective case-control study. Eur J Gastro Hepatol. 2020. https://doi.org/10.1097/MEG.0000000000001902 - PubMed
- Bramante C, Tignanelli CJ, Dutta N, et al. Non-alcoholic fatty liver disease (NAFLD) and risk of hospitalization for Covid-19. medRxiv. https://doi.org/10.1101/2020.09.01.20185850 - PubMed
- Gao Y, Chen Y, Liu M, Shi S, Tian J. Impacts of immunosuppression and immunodeficiency on COVID-19: A systematic review and meta-analysis. The Journal of Infection. 2020;81(2):e93-e95. - PubMed
- Gao F, Zheng KI, Gu JY, George J, Zheng MH. COVID-19 and liver transplantation: Lessons learned from three reported cases. Transpl Infect Dis. 2020;22(4):e13335. - PubMed
- Varghese J, Malleeswaran S, Patcha RV, et al. A multicentric experience on living donor liver transplantation in COVID-19 hotspots in India. Liver Transpl n/a(n/a). - PubMed
- Fernández-Ruiz M, Andrés A, Loinaz C, et al. COVID-19 in solid organ transplant recipients: A single-center case series from Spain. Am J Transplant. 2020;20(7):1849-1858. - PubMed
- Webb GJ, Moon AM, Barnes E, Barritt AS, Marjot T. Determining risk factors for mortality in liver transplant patients with COVID-19. Lancet Gastroenterol Hepatol. 2020;5(7):643-644. - PubMed
- Heimbach JK, Taner T. SARS-CoV-2 infection in liver transplant recipients: collaboration in the time of COVID-19. Lancet Gastroenterol Hepatol. 2020;5(11):958-960. - PubMed
- Bhoori S, Rossi RE, Citterio D, Mazzaferro V. COVID-19 in long-term liver transplant patients: preliminary experience from an Italian transplant centre in Lombardy. Lancet Gastroenterol Hepatol. 2020;5(6):532-533. - PubMed
- Deng G, Yin M, Chen X, Zeng F. Clinical determinants for fatality of 44,672 patients with COVID-19. Crit Care. 2020;24(1):179. - PubMed
- Kuderer NM, Choueiri TK, Shah DP, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet. 2020;395(10241):1907-1918. - PubMed
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