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Banerjee S, Hayes AM, Shapiro BH. Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors. Endocr Connect. 2021;10(9):1167-1179doi: 10.1530/EC-21-0143.
Banerjee, S., Hayes, A. M., & Shapiro, B. H. (2021). Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors. Endocrine connections, 10(9), 1167-1179. https://doi.org/10.1530/EC-21-0143
Banerjee, Sarmistha, et al. "Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors." Endocrine connections vol. 10,9 (2021): 1167-1179. doi: https://doi.org/10.1530/EC-21-0143
Banerjee S, Hayes AM, Shapiro BH. Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors. Endocr Connect. 2021 Sep 20;10(9):1167-1179. doi: 10.1530/EC-21-0143. PMID: 34424855; PMCID: PMC8494408.
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Endocr Connect. 2021 Sep 20;10(9):1167-1179. doi: 10.1530/EC-21-0143.

Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors.

Endocrine connections

Sarmistha Banerjee, Allison M Hayes, Bernard H Shapiro

Affiliations

  1. Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

PMID: 34424855 PMCID: PMC8494408 DOI: 10.1530/EC-21-0143

Abstract

The sexually dimorphic expression of cytochromes P450 (CYP) drug metabolizing enzymes has been reported in all species examined. These sex differences are initially expressed during puberty and are solely regulated by sex differences in the circulating growth hormone (GH) profiles. Once established, however, the different male- and female-dependent CYP isoforms are permanent and immutable, suggesting that adult CYP expression requires imprinting. Since the hormone that regulates an adult function is likely the same hormone that imprints the function, we selectively blocked GH secretion in some newborn male rats while others also received a concurrent physiologic replacement of rat GH. Rats were subsequently challenged, peripubertally, with either a masculine-like episodic GH regimen or the GH vehicle alone. The results demonstrate that episodic GH regulation of male-specific CYP2C11 and CYP3A2, as well as female-predominant CYP2C6, are dependent on developmental GH imprinting. Moreover, the induction and/or activation of major components in the signal transduction pathway regulating the expression of the principal CYP2C11 isoform is obligatorily dependent on perinatal GH imprinting without which CYP2C11 and drug metabolism would be permanently and profoundly suppressed. Since there are additional adult metabolic functions also regulated by GH, pediatric drug therapy that is known to disrupt GH secretion could unintentionally impair adult health.

Keywords: CYP; P450s; growth hormone; imprinting; sexual dimorphism; transcription factors

References

  1. Endocrinology. 2011 Dec;152(12):4813-24 - PubMed
  2. Endocrinology. 2000 Sep;141(9):3245-55 - PubMed
  3. J Pharmacol Exp Ther. 2002 Aug;302(2):490-6 - PubMed
  4. Mol Cell Endocrinol. 1999 Aug 20;154(1-2):37-43 - PubMed
  5. Biochem Pharmacol. 1991 May 1;41(9):1299-309 - PubMed
  6. J Biol Chem. 1988 Aug 15;263(23):11396-406 - PubMed
  7. J Endocrinol. 2017 Mar;232(3):377-389 - PubMed
  8. Drug Metab Dispos. 2006 Mar;34(3):410-9 - PubMed
  9. J Endocrinol. 2013 Jan 02;216(1):87-97 - PubMed
  10. Prog Clin Biol Res. 1985;171:151-73 - PubMed
  11. J Pharmacol Exp Ther. 2000 Jun;293(3):1027-33 - PubMed
  12. J Pharmacol Exp Ther. 2000 Jan;292(1):228-37 - PubMed
  13. Dev Biol. 2014 Dec 15;396(2):201-13 - PubMed
  14. J Biol Chem. 2000 Nov 3;275(44):34173-82 - PubMed
  15. Mol Cell Endocrinol. 2019 Jan 5;479:27-38 - PubMed
  16. Mol Pharmacol. 1996 Nov;50(5):1148-56 - PubMed
  17. Endocrinology. 1984 Sep;115(3):996-1003 - PubMed
  18. Endocr Res. 2013;38(2):105-11 - PubMed
  19. Mol Cell Endocrinol. 2001 Feb 28;173(1-2):167-81 - PubMed
  20. Acta Endocrinol (Copenh). 1991 Mar;124(3):283-9 - PubMed
  21. Neuroendocrinology. 1992 Nov;56(5):619-25 - PubMed
  22. Endocrinology. 1999 Aug;140(8):3693-704 - PubMed
  23. J Pharmacol Exp Ther. 2006 Jan;316(1):87-94 - PubMed
  24. J Clin Invest. 2005 Feb;115(2):233-6 - PubMed
  25. Science. 1980 Jul 18;209(4454):418-20 - PubMed
  26. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12309-13 - PubMed
  27. J Pharmacol Exp Ther. 1993 May;265(2):979-84 - PubMed
  28. Br J Pharmacol. 2013 Feb;168(4):988-1000 - PubMed
  29. Endocrinology. 2007 Jun;148(6):2894-903 - PubMed
  30. Mol Cell Endocrinol. 2004 May 31;220(1-2):31-9 - PubMed
  31. Drug Metab Dispos. 2008 Sep;36(9):1884-95 - PubMed
  32. Lab Invest. 2018 Nov;98(11):1500-1511 - PubMed
  33. Biochemistry. 1985 Jul 30;24(16):4409-17 - PubMed
  34. Mol Pharmacol. 1996 Mar;49(3):523-31 - PubMed
  35. Mol Pharmacol. 1990 Aug;38(2):192-7 - PubMed
  36. FASEB J. 2014 Sep;28(9):4111-22 - PubMed
  37. Endocrinology. 1979 Aug;105(2):555-60 - PubMed
  38. Endocrinology. 1999 Mar;140(3):1245-54 - PubMed
  39. Mol Endocrinol. 2009 Nov;23(11):1914-26 - PubMed
  40. Biotechniques. 2002 Apr;32(4):776-8, 780, 782 - PubMed
  41. Int J Biochem Cell Biol. 1995 Jan;27(1):9-20 - PubMed
  42. Pharmacol Res. 2016 Sep;111:784-803 - PubMed
  43. Drug Metab Dispos. 2007 Nov;35(11):2102-10 - PubMed
  44. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6868-72 - PubMed
  45. Am J Physiol. 1995 Mar;268(3 Pt 1):E439-45 - PubMed
  46. Drug Metab Dispos. 2001 Feb;29(2):111-20 - PubMed
  47. Mol Hum Reprod. 2018 Nov 1;24(11):533-542 - PubMed
  48. Mol Pharmacol. 2005 Mar;67(3):891-901 - PubMed
  49. J Biol Chem. 1985 Oct 5;260(22):11895-8 - PubMed
  50. Mol Pharmacol. 1995 Nov;48(5):790-7 - PubMed
  51. Biotechniques. 1995 Apr;18(4):588-90 - PubMed
  52. Mol Pharmacol. 2009 Aug;76(2):215-28 - PubMed
  53. Neuroendocrinology. 1978;26(4):220-8 - PubMed
  54. Endocrinology. 1989 Dec;125(6):2935-44 - PubMed
  55. Endocrinology. 2000 Oct;141(10):3527-33 - PubMed
  56. Cell Biochem Funct. 2008 Jan-Feb;26(1):1-10 - PubMed
  57. FASEB J. 1992 Jan 6;6(2):711-8 - PubMed

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