Display options
Cite
Chiba S, Okawara T, Kawakami K, et al. Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala. Physiol Behav. 2021;245:113670doi: 10.1016/j.physbeh.2021.113670.
Chiba, S., Okawara, T., Kawakami, K., Ohta, R., & Kawaguchi, M. (2021). Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala. Physiology & behavior, 245113670. https://doi.org/10.1016/j.physbeh.2021.113670
Chiba, Shuichi, et al. "Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala." Physiology & behavior vol. 245 (2021): 113670. doi: https://doi.org/10.1016/j.physbeh.2021.113670
Chiba S, Okawara T, Kawakami K, Ohta R, Kawaguchi M. Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala. Physiol Behav. 2021 Dec 08;245:113670. doi: 10.1016/j.physbeh.2021.113670. Epub 2021 Dec 08. PMID: 34890592.
Copy Download .nbib Format: NLM
Share it on

Physiol Behav. 2021 Dec 08;245:113670. doi: 10.1016/j.physbeh.2021.113670. Epub 2021 Dec 08.

Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala.

Physiology & behavior

Shuichi Chiba, Toru Okawara, Kotaro Kawakami, Ryo Ohta, Maiko Kawaguchi

Affiliations

  1. Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoino-Oka, Imabari, Ehime 794-8555, Japan.
  2. School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
  3. Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano,Kanagawa 257-8523, Japan.
  4. School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan. Electronic address: [email protected].

PMID: 34890592 DOI: 10.1016/j.physbeh.2021.113670

Abstract

Growing evidence supports interactions between anxiety and cognitive function. The primary object of this study was to elucidate whether high-avoidance (HAA) and low-avoidance (LAA) strains of Hatano rats are suitable for the analysis of interactions between the formation of long-term memory and emotional reactivity. The learning/memory ability of Hatano rats and their Sprague-Dawley (SD) ancestors was evaluated using contextual fear conditioning, Y-maze, and Barnes maze tests from 8 weeks of age. Ultrasonic vocalizations were recorded and analyzed during contextual fear conditioning. In a separate experiment, rat brains were sampled 90 min after the first context test and subjected to Nissl staining and c-fos immunostaining. The duration of freezing and number of 22 kHz ultrasonic vocalizations were decreased in LAA compared with HAA and SD rats during the first and second context tests of contextual fear conditioning. The HAA rats did not show preferences for quadrants during the Barnes maze probe test, whereas the SD and LAA rats spent significantly more time in the quadrant where the goals had been placed. There was no difference among the strains in short-term spatial memory as shown by the Y-maze test. Decreases were found in the number of c-fos

Copyright © 2021. Published by Elsevier Inc.

Keywords: Barnes maze; Contextual fear conditioning; Hatano rats; Hippocampus; Spatial learning; Ultrasonic vocalization

Publication Types