Display options
Cite
Geboers B, Timmer FEF, van den Tol PM, et al. Irreversibele elektroporatie. [Irreversible electroporation: local tumor ablation with systemic immune effect]. Ned Tijdschr Geneeskd. 2021;165
Geboers, B., Timmer, F. E. F., van den Tol, P. M., de Gruijl, T. D., Scheffer, H. J., & Meijerink, M. R. (2021). Irreversibele elektroporatie. [Irreversible electroporation: local tumor ablation with systemic immune effect]. Nederlands tijdschrift voor geneeskunde, 165.
Geboers, Bart, et al. "Irreversibele elektroporatie." [Irreversible electroporation: local tumor ablation with systemic immune effect]. Nederlands tijdschrift voor geneeskunde vol. 165 (2021).
Geboers B, Timmer FEF, van den Tol PM, de Gruijl TD, Scheffer HJ, Meijerink MR. Irreversibele elektroporatie. [Irreversible electroporation: local tumor ablation with systemic immune effect]. Ned Tijdschr Geneeskd. 2021 Sep 20;165. Dutch. PMID: 34854585.
Copy Download .nbib Format: NLM
Share it on

Ned Tijdschr Geneeskd. 2021 Sep 20;165.

[Irreversible electroporation: local tumor ablation with systemic immune effect].

Nederlands tijdschrift voor geneeskunde

[Article in Dutch]
Bart Geboers, Florentine E F Timmer, Petrousjka M van den Tol, Tanja D de Gruijl, Hester J Scheffer, Martijn R Meijerink

Affiliations

  1. Amsterdam UMC, locatie VUmc, Cancer Center Amsterdam, Amsterdam: Afd. Radiologie en Nucleaire Geneeskunde.
  2. Amsterdam UMC, locatie VUmc, Cancer Center Amsterdam, Amsterdam: Afd. Chirurgie.
  3. Amsterdam UMC, locatie VUmc, Cancer Center Amsterdam, Amsterdam: Afd. Medische Oncologie.
  4. Contact: Martijn R. Meijerink ([email protected]).

PMID: 34854585

Abstract

Irreversible electroporation (IRE) employs high-voltage electrical pulses for non-thermal image-guided tumor ablation in solid organs. The pulses disrupt the membrane potential of all cells within the ablation zone causing loss of tumour cell homeostasis resulting in death. IRE has the advantage of sparing extracellular matrix structures and thereby preserving the anatomical integrity of blood vessels, bile ducts, and ureters. This trait distinguishes IRE from more commonly used thermal ablation techniques like microwave- and radiofrequency ablation. Several prospective phase-1 and -2 studies demonstrated the safety and efficacy of IRE for the treatment of central liver, locally advanced pancreatic, and local prostate tumours. In addition, IRE induces a systemic immune response. When this immune effect can be amplified by combinatory treatment with immunotherapeutic drugs its synergy might form a bridge between local and systemic therapies with the potential to develop into a fundamentally new approach to cancer treatment.

Publication Types