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Velikkakam T, Gollob KJ, Dutra WO. Double-negative T cells: Setting the stage for disease control or progression. Immunology. 2021;doi: 10.1111/imm.13441.
Velikkakam, T., Gollob, K. J., & Dutra, W. O. (2021). Double-negative T cells: Setting the stage for disease control or progression. Immunology, . https://doi.org/10.1111/imm.13441
Velikkakam, Teresiama, et al. "Double-negative T cells: Setting the stage for disease control or progression." Immunology vol. (2021). doi: https://doi.org/10.1111/imm.13441
Velikkakam T, Gollob KJ, Dutra WO. Double-negative T cells: Setting the stage for disease control or progression. Immunology. 2021 Dec 22; doi: 10.1111/imm.13441. Epub 2021 Dec 22. PMID: 34939192.
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Immunology. 2021 Dec 22; doi: 10.1111/imm.13441. Epub 2021 Dec 22.

Double-negative T cells: Setting the stage for disease control or progression.

Immunology

Teresiama Velikkakam, Kenneth J Gollob, Walderez Ornelas Dutra

Affiliations

  1. Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  2. Pós-graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  3. Hospital Israelita Albert Einsten, São Paulo, Brazil.
  4. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais - INCT-DT, Belo Horizonte, Brazil.

PMID: 34939192 DOI: 10.1111/imm.13441

Abstract

Double-negative (DN) T cells are present at relatively low frequencies in human peripheral blood, and are characterized as expressing the alpha-beta or gamma-delta T-cell receptor (TCR), but not the CD4 nor the CD8 co-receptors. Despite their low frequencies, these cells are potent producers of cytokines and, thus, are key orchestrators of immune responses. DN T cells were initially associated with induction of peripheral immunological tolerance and immunomodulatory activities related to disease prevention. However, other studies demonstrated that these cells can also display effector functions associated with pathology development. This apparent contradiction highlighted the heterogeneity of the DN T-cell population. Here, we review phenotypic and functional characteristics of DN T cells, emphasizing their role in human diseases. The need for developing biomarkers to facilitate the translation of studies from animal models to humans will also be discussed. Finally, we will examine DN T cells as promising therapeutic targets to prevent or inhibit human disease development.

© 2022 John Wiley & Sons Ltd.

Keywords: cancer; double-negative T cells; immunoregulation; inflammatory diseases; parasitic diseases

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