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Lipman ZM, Paramasivam V, Yosipovitch G, et al. Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches. Clin Kidney J. 2021;14:i16-i22doi: 10.1093/ckj/sfab167.
Lipman, Z. M., Paramasivam, V., Yosipovitch, G., & Germain, M. J. (2021). Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches. Clinical kidney journal, 14i16-i22. https://doi.org/10.1093/ckj/sfab167
Lipman, Zoe M, et al. "Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches." Clinical kidney journal vol. 14 (2021): i16-i22. doi: https://doi.org/10.1093/ckj/sfab167
Lipman ZM, Paramasivam V, Yosipovitch G, Germain MJ. Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches. Clin Kidney J. 2021 Oct 14;14:i16-i22. doi: 10.1093/ckj/sfab167. eCollection 2021 Dec. PMID: 34987779; PMCID: PMC8702820.
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Clin Kidney J. 2021 Oct 14;14:i16-i22. doi: 10.1093/ckj/sfab167. eCollection 2021 Dec.

Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches.

Clinical kidney journal

Zoe M Lipman, Vijayakumar Paramasivam, Gil Yosipovitch, Michael J Germain

Affiliations

  1. Dr Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, FL, USA.
  2. Division of Nephrology, Renal Transplant Associates of New England, Baystate Medical Center U Mass Medical School, Springfield, MA, USA.

PMID: 34987779 PMCID: PMC8702820 DOI: 10.1093/ckj/sfab167

Abstract

Chronic kidney disease (CKD)-associated pruritus (CKD-aP) is an underdiagnosed yet severely distressing condition that impacts 60% of patients on dialysis and many nondialysis patients with Stages 3-5 CKD. However, despite its high prevalence, there are currently limited treatment options available for these patients and a lack of treatment guidelines for clinicians. In this manuscript, we reviewed the available literature in order to evaluate the current management and treatment options for CKD-aP, including dialysis management, topical treatments, gabapentinoids, opioids and alternative medicine. We also review the available data on CKD-aP treatments in development and propose new guidelines for managing patients with CKD-aP.

© The Author(s) 2021. Published by Oxford University Press on behalf of ERA.

Keywords: CKD; CKD-aP; ESRD; itch; pruritus; uremic pruritus

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