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Bansal P, Morgat A, Axelsen KB, et al. Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022;50:D693-D700doi: 10.1093/nar/gkab1016.
Bansal, P., Morgat, A., Axelsen, K. B., Muthukrishnan, V., Coudert, E., Aimo, L., Hyka-Nouspikel, N., Gasteiger, E., Kerhornou, A., Neto, T. B., Pozzato, M., Blatter, M. C., Ignatchenko, A., Redaschi, N., & Bridge, A. (2022). Rhea, the reaction knowledgebase in 2022. Nucleic acids research, 50D693-D700. https://doi.org/10.1093/nar/gkab1016
Bansal, Parit, et al. "Rhea, the reaction knowledgebase in 2022." Nucleic acids research vol. 50 (2022): D693-D700. doi: https://doi.org/10.1093/nar/gkab1016
Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A. Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 07;50:D693-D700. doi: 10.1093/nar/gkab1016. PMID: 34755880; PMCID: PMC8728268.
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Nucleic Acids Res. 2022 Jan 07;50:D693-D700. doi: 10.1093/nar/gkab1016.

Rhea, the reaction knowledgebase in 2022.

Nucleic acids research

Parit Bansal, Anne Morgat, Kristian B Axelsen, Venkatesh Muthukrishnan, Elisabeth Coudert, Lucila Aimo, Nevila Hyka-Nouspikel, Elisabeth Gasteiger, Arnaud Kerhornou, Teresa Batista Neto, Monica Pozzato, Marie-Claude Blatter, Alex Ignatchenko, Nicole Redaschi, Alan Bridge

Affiliations

  1. Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  2. EMBL-EBI European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

PMID: 34755880 PMCID: PMC8728268 DOI: 10.1093/nar/gkab1016

Abstract

Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

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