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Signal Transduct Target Ther. 2022 Jan 04;7(1):5. doi: 10.1038/s41392-021-00864-1.

Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution.

Signal transduction and targeted therapy

Yier Lu, Chenyang Ye, Ying Yuan

Affiliations

  1. Department of Medical Oncology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
  2. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China.
  3. Department of Medical Oncology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China. [email protected].
  4. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China. [email protected].
  5. Department of Medical Oncology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China. [email protected].
  6. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China. [email protected].

PMID: 34983923 DOI: 10.1038/s41392-021-00864-1

[No abstract available.]

References

  1. Oliveira, G. et al. Phenotype, specificity and avidity of antitumour CD8(+) T cells in melanoma. Nature 596, 119–125 (2021). - PubMed
  2. Simoni, Y. et al. Bystander CD8 - PubMed
  3. Li, H. et al. Dysfunctional CD8 - PubMed
  4. Thommen, D. S. et al. A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Nat. Med. 24, 994–1004 (2018). - PubMed
  5. Park, S. L. et al. Tissue-resident memory CD8 - PubMed

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