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Taskiran E, Kemerdere R, Akgun MY, et al. Health-related Quality of Life Assessment in Patients with Malignant Gliomas. Neurol India. 2021;69(6):1613-1618doi: 10.4103/0028-3886.333476.
Taskiran, E., Kemerdere, R., Akgun, M. Y., Cetintas, S. C., Alizada, O., Kacira, T., & Tanriverdi, T. (2021). Health-related Quality of Life Assessment in Patients with Malignant Gliomas. Neurology India, 69(6), 1613-1618. https://doi.org/10.4103/0028-3886.333476
Taskiran, Emine, et al. "Health-related Quality of Life Assessment in Patients with Malignant Gliomas." Neurology India vol. 69,6 (2021): 1613-1618. doi: https://doi.org/10.4103/0028-3886.333476
Taskiran E, Kemerdere R, Akgun MY, Cetintas SC, Alizada O, Kacira T, Tanriverdi T. Health-related Quality of Life Assessment in Patients with Malignant Gliomas. Neurol India. 2021 Nov-Dec;69(6):1613-1618. doi: 10.4103/0028-3886.333476. PMID: 34979651.
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Neurol India. 2021 Nov-Dec;69(6):1613-1618. doi: 10.4103/0028-3886.333476.

Health-related Quality of Life Assessment in Patients with Malignant Gliomas.

Neurology India

Emine Taskiran, Rahsan Kemerdere, Mehmet Y Akgun, Semih C Cetintas, Orkhan Alizada, Tibet Kacira, Taner Tanriverdi

Affiliations

  1. Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey.
  2. Department of Neurosurgery, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey.
  3. Department of Neurosurgery, K?r?kkale Yuksek Ihtisas Research and Training Hospital, Kirikkale, Turkey.
  4. Department of Neurosurgery, Baskent University, Medical Faculty, Istanbul, Turkey.
  5. Department of Neurosurgery, Sakarya University Training and Research Hospital, Sakarya, Turkey.

PMID: 34979651 DOI: 10.4103/0028-3886.333476

Abstract

BACKGROUND: High-grade gliomas have limited time of survival despite aggressive treatment. Patients experience a decline in their physical and mental capacities, affecting their quality of life (QoL), and require proper therapeutic strategies.

OBJECTIVE: To assess the QoL of malignant glioma patients before and after the treatment in a longitudinal study of six months.

METHODS AND MATERIAL: Forty-nine patients who were pathologically diagnosed with glioblastoma and anaplastic glioma according to WHO 2016 were included in this prospective study. The assessment of quality of life was done using the European Organization for Research and Treatment of Cancer (EORTC) quality of life (QoL) questionnaire core-30 prior to surgery, 1 and 5 months after the operation.

RESULTS: The decline in Karnofsky scores of the patients was statistically significant. Among the symptom scales, fatigue was more prominent after surgery while pain was noticeable during chemotherapy which was correlated with increased age. The mean overall QoL scores showed a clinically significant decline during the postoperative period. The functional scores demonstrated a significant decline in between all periods. Sex was significantly correlated with preoperative emotional and physical functioning. The patients with right-sided lesions had higher mean scores for social and cognitive functioning.

CONCLUSIONS: Low KPS, older age, and female gender may affect cancer symptoms and physical and social activities in malignant glioma patients. Cognitive functions as well as social and occupational roles gradually decline during the first six months of treatments. Overall QoL of high-grade glioma patients deteriorates especially after radiotherapy and during the first months of chemotherapy.

Keywords: EORTC; glioma; high grade; quality of life

Conflict of interest statement

None

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