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Goletto T, Decaux S, Bunel V, et al. Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports. J Med Case Rep. 2022;16(1):2doi: 10.1186/s13256-021-03191-9.
Goletto, T., Decaux, S., Bunel, V., Weisenburger, G., Messika, J., Najem, S., Medraoui, C., Godet, C., Debray, M. P., Lortat-Jacob, B., Mordant, P., Castier, Y., Bouadma, L., Borie, R., & Mal, H. (2022). Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports. Journal of medical case reports, 16(1), 2. https://doi.org/10.1186/s13256-021-03191-9
Goletto, Tiphaine, et al. "Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports." Journal of medical case reports vol. 16,1 (2022): 2. doi: https://doi.org/10.1186/s13256-021-03191-9
Goletto T, Decaux S, Bunel V, Weisenburger G, Messika J, Najem S, Medraoui C, Godet C, Debray MP, Lortat-Jacob B, Mordant P, Castier Y, Bouadma L, Borie R, Mal H. Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports. J Med Case Rep. 2022 Jan 03;16(1):2. doi: 10.1186/s13256-021-03191-9. PMID: 34980231.
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J Med Case Rep. 2022 Jan 03;16(1):2. doi: 10.1186/s13256-021-03191-9.

Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports.

Journal of medical case reports

Tiphaine Goletto, Sixtine Decaux, Vincent Bunel, Gaëlle Weisenburger, Jonathan Messika, Samer Najem, Chahine Medraoui, Cendrine Godet, Marie Pierre Debray, Brice Lortat-Jacob, Pierre Mordant, Yves Castier, Lila Bouadma, Raphael Borie, Hervé Mal

Affiliations

  1. Service de Pneumologie B, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018, Paris, France.
  2. Inserm UMR1152, Université Paris7 Denis Diderot, 75018, Paris, France.
  3. Service de Radiologie, Hôpital Bichat, Paris, France.
  4. Service de Réanimation Chirurgicale, Hôpital Bichat, Paris, France.
  5. Service de Chirurgie Vasculaire, Thoracique et Transplantation Pulmonaire, Hôpital Bichat, Paris, France.
  6. Service de Réanimation Médicale et Infectieuse, Hôpital Bichat, Paris, France.
  7. Service de Pneumologie A, Hôpital Bichat, Paris, France.
  8. Service de Pneumologie B, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018, Paris, France. [email protected].
  9. Inserm UMR1152, Université Paris7 Denis Diderot, 75018, Paris, France. [email protected].
  10. Service de Pneumologie B et Transplantation Pulmonaire, Hôpital Bichat, 46 rue Henri Huchard, 75018, Paris, France. [email protected].

PMID: 34980231 DOI: 10.1186/s13256-021-03191-9

Abstract

BACKGROUND: In patients receiving single lung transplantation for idiopathic pulmonary fibrosis, worsening of fibrosis of the native lung is usually progressive over time, with no significant effects on gas exchange.

CASE PRESENTATION: Here, we describe the cases of two Caucasian male recipients of single lung transplants for idiopathic pulmonary fibrosis, 65 and 62 years of age, who exhibited acute worsening of lung fibrosis after an episode of serious viral infection (cytomegalovirus primo-infection in one case and COVID-19 in the other). In both cases, along with opacification of the native lung over several days, the patients presented acute respiratory failure that required the use of high-flow nasal oxygen therapy. Eventually, hypoxemic respiratory failure resolved, but with rapid progression of fibrosis of the native lung.

CONCLUSION: We conclude that acute worsening of fibrosis on the native lung secondary to a severe viral infection should be added to the list of potential complications developing on the native lung after single lung transplantation for idiopathic pulmonary fibrosis.

© 2022. The Author(s).

Keywords: Hypoxemia; Idiopathic pulmonary fibrosis; Lung fibrosis; Lung infection; Lung transplantation

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