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Zizzari IG, Di Filippo A, Botticelli A, et al. Circulating CD137. Clin Cancer Res. 2022;doi: 10.1158/1078-0432.CCR-21-2918.
Zizzari, I. G., Di Filippo, A., Botticelli, A., Strigari, L., Pernazza, A., Rullo, E., Pignataro, M. G., Ugolini, A., Scirocchi, F., Di Pietro, F. R., Rossi, E., Gelibter, A., Schinzari, G., d'Amati, G., Rughetti, A., Marchetti, P., Nuti, M., & Napoletano, C. (2022). Circulating CD137. Clinical cancer research : an official journal of the American Association for Cancer Research, . https://doi.org/10.1158/1078-0432.CCR-21-2918
Zizzari, Ilaria Grazia, et al. "Circulating CD137." Clinical cancer research : an official journal of the American Association for Cancer Research vol. (2022). doi: https://doi.org/10.1158/1078-0432.CCR-21-2918
Zizzari IG, Di Filippo A, Botticelli A, Strigari L, Pernazza A, Rullo E, Pignataro MG, Ugolini A, Scirocchi F, Di Pietro FR, Rossi E, Gelibter A, Schinzari G, d'Amati G, Rughetti A, Marchetti P, Nuti M, Napoletano C. Circulating CD137. Clin Cancer Res. 2022 Jan 03; doi: 10.1158/1078-0432.CCR-21-2918. Epub 2022 Jan 03. PMID: 34980602.
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Clin Cancer Res. 2022 Jan 03; doi: 10.1158/1078-0432.CCR-21-2918. Epub 2022 Jan 03.

Circulating CD137.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ilaria Grazia Zizzari, Alessandra Di Filippo, Andrea Botticelli, Lidia Strigari, Angelina Pernazza, Emma Rullo, Maria Gemma Pignataro, Alessio Ugolini, Fabio Scirocchi, Francesca Romana Di Pietro, Ernesto Rossi, Alain Gelibter, Giovanni Schinzari, Giulia d'Amati, Aurelia Rughetti, Paolo Marchetti, Marianna Nuti, Chiara Napoletano

Affiliations

  1. Department of Experimental Medicine, Sapienza University of Rome.
  2. Department of Experimental Medicine, Policlinico Umberto I, Sapienza University.
  3. Oncology Unit, Department of Clinical and Molecular Medicine, Sapienza University of Rome.
  4. medical physics.
  5. Sapienza University of Rome.
  6. Immunology, Moffitt Cancer Center.
  7. Oncology, Istituto Dermopatico dell'Immacolata.
  8. Department of Medical Oncology, Fondazione Policlinico A. Gemelli.
  9. Department of Medical Oncology, Policlinico Umberto I.
  10. Agostino Gemelli University Polyclinic.
  11. Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome.
  12. Experimental Medicine, Sapienza University of Rome.
  13. Department of Experimental Medicine, Sapienza University of Rome [email protected].

PMID: 34980602 DOI: 10.1158/1078-0432.CCR-21-2918

Abstract

PURPOSE: CD137 molecule is expressed by activated lymphocytes, and in cancer patients identifies the tumor-reactive Tcells. In solid tumors, high levels of circulating CD137

EXPERIMENTAL DESIGN: PBMC derived from 109 metastatic cancer patients (66 patients for the identification cohort and 43 for the validation cohort) were analysed for the expression of CD3,CD4,CD8,CD137 and PD1 molecules before the beginning of anti-PD1 therapy. Twenty-healthy donors were used as control. The soluble form of CD137(sCD137) was also analysed. The CD137

RESULTS: The percentage of CD137

CONCLUSIONS: We propose the CD137

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