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Langenbecks Arch Surg. 2022 Jan 03; doi: 10.1007/s00423-021-02419-y. Epub 2022 Jan 03.

The Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) trial results cast doubt upon benefit of lung and liver metastasectomy at the time colorectal resection.

Langenbeck's archives of surgery

Norman R Williams, Tom Treasure, Fergus Macbeth

Affiliations

  1. Surgical and Interventional Trials Unit (SITU), University College London, London, UK.
  2. Clinical Operational Research Unit (CORU), University College London, London, UK. [email protected].
  3. Centre for Trials Research, Cardiff University, Cardiff, UK.

PMID: 34981188 DOI: 10.1007/s00423-021-02419-y

[No abstract available.]

References

  1. Tanaka Y, Yamaoka Y, Shiomi A, Kagawa H, Hino H, Manabe S et al (2021) Clinical outcomes following colorectal resection of colorectal cancer with simultaneous hepatic and pulmonary metastases at the time of diagnosis. Langenbecks Arch Surg - PubMed
  2. Treasure T, Farewell V, Macbeth F, Batchelor T, Milosevic M, King J et al (2021) The Pulmonary Metastasectomy in Colorectal Cancer cohort study: analysis of case selection, risk factors and survival in a prospective observational study of 512 patients. Colorectal Dis 23(7):1793–1803 - PubMed
  3. Milosevic M, Edwards J, Tsang D, Dunning J, Shackcloth M, Batchelor T et al (2020) Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients - control survival is much better than previously assumed. Colorectal Dis 22(10):1314–1324 - PubMed
  4. Treasure T, Farewell V, Macbeth F, Monson K, Williams NR, Brew-Graves C et al (2019) Pulmonary Metastasectomy versus Continued Active Monitoring in Colorectal Cancer (PulMiCC): a multicentre randomised clinical trial. Trials 20(1):718 - PubMed
  5. Brew-Graves C, Farewell V, Monson K, Milosevic M, Williams NR, Morris E et al (2021) Pulmonary metastasectomy in colorectal cancer: health utility scores by EQ-5D-3L in a randomized controlled trial show no benefit from lung metastasectomy. Colorectal Dis 23(1):200–205 - PubMed
  6. Glasziou P, Chalmers I, Rawlins M, McCulloch P (2007) When are randomised trials unnecessary? Picking signal from noise BMJ 334(7589):349–351 - PubMed

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