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Dunn WG, Gu MS, Fabre MA, et al. The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients. Ann Hematol. 2021;101(2):443-445doi: 10.1007/s00277-021-04472-5.
Dunn, W. G., Gu, M. S., Fabre, M. A., Cooper, J., Nomdedeu, J. F., Koumas, L., Nicolaou, K., Chi, J., Costeas, P., & Vassiliou, G. S. (2022). The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients. Annals of hematology, 101(2), 443-445. https://doi.org/10.1007/s00277-021-04472-5
Dunn, William G, et al. "The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients." Annals of hematology vol. 101,2 (2022): 443-445. doi: https://doi.org/10.1007/s00277-021-04472-5
Dunn WG, Gu MS, Fabre MA, Cooper J, Nomdedeu JF, Koumas L, Nicolaou K, Chi J, Costeas P, Vassiliou GS. The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients. Ann Hematol. 2022 Feb;101(2):443-445. doi: 10.1007/s00277-021-04472-5. Epub 2021 Mar 01. PMID: 33650061.
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Ann Hematol. 2022 Feb;101(2):443-445. doi: 10.1007/s00277-021-04472-5. Epub 2021 Mar 01.

The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients.

Annals of hematology

William G Dunn, Muxin S Gu, Margarete A Fabre, Jonathan Cooper, Josep F Nomdedeu, Laura Koumas, Katerina Nicolaou, Jiangxiang Chi, Paul Costeas, George S Vassiliou

Affiliations

  1. Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK.
  2. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.
  3. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  4. Department of Haematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.
  5. Center for the Study of Haematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus.
  6. Center for the Study of Haematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus. [email protected].
  7. Cyprus Cancer Research Institute, Nicosia, Cyprus. [email protected].
  8. Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK. [email protected].
  9. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK. [email protected].
  10. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. [email protected].
  11. Center for the Study of Haematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus. [email protected].
  12. Cyprus Cancer Research Institute, Nicosia, Cyprus. [email protected].

PMID: 33650061 DOI: 10.1007/s00277-021-04472-5

[No abstract available.]

References

  1. de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A (Aug 1991) The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell. 66(4):675–684. https://doi.org/10.1016/0092-8674(91)90113-d - PubMed
  2. Wojiski S, Guibal FC, Kindler T, Lee BH, Jesneck JL, Fabian A, Tenen DG, Gilliland DG (Aug 2009) PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors. Leukemia. 23(8):1462–1471. https://doi.org/10.1038/leu.2009.63 - PubMed
  3. Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O’Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ (Jun 2016) Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med 374(23):2209–2221. https://doi.org/10.1056/NEJMoa1516192 - PubMed
  4. Madan V, Shyamsunder P, Han L et al (2016) Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia 30(12):2430. https://doi.org/10.1038/leu.2016.237 - PubMed
  5. Westervelt P, Lane AA, Pollock JL, Oldfather K, Holt MS, Zimonjic DB, Popescu NC, DiPersio JF, Ley TJ (Sep 2003) High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 102(5):1857–1865. https://doi.org/10.1182/blood-2002-12-3779 - PubMed
  6. Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ (Jan 1997) Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood. 89(2):376–387 - PubMed
  7. Abelson S, Collord G, Ng SWK et al (2018) Prediction of acute myeloid leukaemia risk in healthy individuals. Nature 559(7714):400–404. https://doi.org/10.1038/s41586-018-0317-6 - PubMed
  8. Gu M, Zwiebel M, Ong SH, Boughton N, Nomdedeu J, Basheer F, Nannya Y, Quiros PM, Ogawa S, Cazzola M, Rad R, Butler AP, Vijayabaskar MS, Vassiliou GS (Oct 2019) RNAmut: robust identification of somatic mutations in acute myeloid leukemia using RNA-seq. Haematologica. 105:e290–e293. https://doi.org/10.3324/haematol.2019.230821 - PubMed
  9. Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, Dipersio JF, Chen F, Wilson RK, Ley TJ, Ding L (Dec 2014) Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med 20(12):1472–1478. https://doi.org/10.1038/nm.3733 - PubMed
  10. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL (Dec 2014) Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 371(26):2488–2498. https://doi.org/10.1056/NEJMoa1408617 - PubMed

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