Int J Oncol. 2022 Feb;60(2). doi: 10.3892/ijo.2022.5302. Epub 2022 Jan 04.

Retrospective analysis of the preparation and application of immunotherapy in cancer treatment (Review).

International journal of oncology

Jiachen Lu, Jianing Ding, Zhaoxia Liu, Tingtao Chen

PMID: 34981814 DOI: 10.3892/ijo.2022.5302

Abstract

Monoclonal antibody technology plays a vital role in biomedical and immunotherapy, which greatly promotes the study of the structure and function of genes and proteins. To date, monoclonal antibodies have gone through four stages: murine monoclonal antibody, chimeric monoclonal antibody, humanised monoclonal antibody and fully human monoclonal antibody; thousands of monoclonal antibodies have been used in the fields of biology and medicine, playing a special role in the pathogenesis, diagnosis and treatment of disease. In this review, we compare the advantages and disadvantages of hybridoma technology, phage display technology, ribosome display technology, transgenic mouse technology, single B cell monoclonal antibody generation technologies, and forecast the promising applications of these technologies in clinical medicine, disease diagnosis and tumour treatment.

Keywords: A single B cell monoclonal antibody generation technology; immunotherapy; monoclonal antibody; phage display technology; tumour

Publication Types

• Journal Article