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Yu G, Jian T, Cui S, et al. Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases. Clin Toxicol (Phila). 2022;1-4doi: 10.1080/15563650.2021.2013495.
Yu, G., Jian, T., Cui, S., Shi, L., Kan, B., & Jian, X. (2022). Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases. Clinical toxicology (Philadelphia, Pa.), 1-4. https://doi.org/10.1080/15563650.2021.2013495
Yu, Guangcai, et al. "Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases." Clinical toxicology (Philadelphia, Pa.) vol. (2022): 1-4. doi: https://doi.org/10.1080/15563650.2021.2013495
Yu G, Jian T, Cui S, Shi L, Kan B, Jian X. Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases. Clin Toxicol (Phila). 2022 Jan 04;1-4. doi: 10.1080/15563650.2021.2013495. Epub 2022 Jan 04. PMID: 34982016.
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Clin Toxicol (Phila). 2022 Jan 04;1-4. doi: 10.1080/15563650.2021.2013495. Epub 2022 Jan 04.

Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases.

Clinical toxicology (Philadelphia, Pa.)

Guangcai Yu, Tianzi Jian, Siqi Cui, Longke Shi, Baotian Kan, Xiangdong Jian

Affiliations

  1. Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China.
  2. Department of Digestive Internal Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
  3. School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  4. Department of Geriatric Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.

PMID: 34982016 DOI: 10.1080/15563650.2021.2013495

Abstract

INTRODUCTION: Diquat-related acute kidney injury is well-known. However, neurological disorders caused by diquat are often underestimated, and changes in the imaging findings are rarely reported. We present three cases of acute diquat poisoning resulting in toxic encephalopathy.

CASE REPORT: In the first case, a 20-year-old previously healthy man ingested approximately 80-100 mL of diquat. He developed acute renal failure, neurological disorders, and respiratory failure. Central pontine myelinolysis was considered by magnetic resonance imaging (MRI), 18 days after ingestion. In the second case, a 20-year-old man ingested approximately 100 mL of diquat. Toxic encephalopathy was confirmed by MRI, 13 days after ingestion. Unfortunately, he experienced cardiac arrest and died 18 days after ingestion. In the third case, a 31-year-old previously healthy man ingested approximately 50 mL of diquat. The imaging features of toxic encephalopathy mainly involved the medulla oblongata, pons, midbrain, bilateral brachium pontis, cerebellum, and pedunculus cerebri. He demonstrated significant recovery.

DISCUSSION: Ingestion of diquat can cause acute renal failure, neurological disorders, and respiratory failure. The pons, midbrain, pedunculus cerebri may be the most commonly impaired locations of diquat-related toxic encephalopathy.

Keywords: Diquat poisoning; clinical characteristics; magnetic resonance imaging; toxic encephalopathy

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