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Zhvania M, Japaridze N, Tizabi Y, et al. Anxiety and ultrastructural consequences of chronic mild stress in rats. Neurosci Lett. 2021;771:136390doi: 10.1016/j.neulet.2021.136390.
Zhvania, M., Japaridze, N., Tizabi, Y., Sharikadze, I., Pochkhidze, N., & Cheishvili, L. (2021). Anxiety and ultrastructural consequences of chronic mild stress in rats. Neuroscience letters, 771136390. https://doi.org/10.1016/j.neulet.2021.136390
Zhvania, Mzia, et al. "Anxiety and ultrastructural consequences of chronic mild stress in rats." Neuroscience letters vol. 771 (2021): 136390. doi: https://doi.org/10.1016/j.neulet.2021.136390
Zhvania M, Japaridze N, Tizabi Y, Sharikadze I, Pochkhidze N, Cheishvili L. Anxiety and ultrastructural consequences of chronic mild stress in rats. Neurosci Lett. 2021 Dec 09;771:136390. doi: 10.1016/j.neulet.2021.136390. Epub 2021 Dec 09. PMID: 34896437.
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Neurosci Lett. 2021 Dec 09;771:136390. doi: 10.1016/j.neulet.2021.136390. Epub 2021 Dec 09.

Anxiety and ultrastructural consequences of chronic mild stress in rats.

Neuroscience letters

Mzia Zhvania, Nadezhda Japaridze, Yousef Tizabi, Irina Sharikadze, Nino Pochkhidze, Levan Cheishvili

Affiliations

  1. School of Natural Sciences and Medicine, Ilia State University. 3/5 K. Cholokashvili Avenue, Tbilisi 0162, Georgia; Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, Tbilisi 0160, Georgia. Electronic address: [email protected].
  2. Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, Tbilisi 0160, Georgia; School of Medicine, New Vision University. 1A Evgeni Mikeladze Street, Tbilisi 0159, Georgia.
  3. Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA.
  4. School of Natural Sciences and Medicine, Ilia State University. 3/5 K. Cholokashvili Avenue, Tbilisi 0162, Georgia.
  5. School of Natural Sciences and Medicine, Ilia State University. 3/5 K. Cholokashvili Avenue, Tbilisi 0162, Georgia; Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, Tbilisi 0160, Georgia.

PMID: 34896437 DOI: 10.1016/j.neulet.2021.136390

Abstract

Detrimental consequences following exposure to severe stress, either acute or chronic are well recognized. Chronic mild stress (CMS) is also a leading cause of emotional distress and neuropsychiatric conditions such as anxiety disorders. However, the neurobiological substrates of the latter, particularly at the ultrastructural levels have not been adequately investigated. In this study, adult male Wistar rats were subjected to 4 h daily mild restraint for 20 days and their behavior in open field and elevated plus maze (EPM) were evaluated 24 h after the last restraint. Anxiety-like behavior was evident in CMS exposed rats by increases in rearing and grooming in the open field and the avoidance of open arms in the EPM. Concomitant ultrastructural alterations such as chromatolysis, agglutination of synaptic vesicles or mitochondrial damage were also observed in the central nucleus of amygdala (CNA), an area intimately involved in emotional and fear response, in CMS exposed rats. These results while confirming detrimental consequences of CMS, also suggest that ultrastructural alterations in CNA may be a basis for CMS-induced anxiety.

Copyright © 2021. Published by Elsevier B.V.

Keywords: Amygdala; Anxiety-like behavior; Chronic restraint stress; Electron microscopy; Elevated-plus maze; Synapse

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