Display options
Cite
Bakre S, Holt SK, Oerline M, et al. Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes. Neurourol Urodyn. 2021;41(1):323-331doi: 10.1002/nau.24823.
Bakre, S., Holt, S. K., Oerline, M., Braffett, B. H., Pop-Busui, R., Wessells, H., Sarma, A. V. (2022). Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes. Neurourology and urodynamics, 41(1), 323-331. https://doi.org/10.1002/nau.24823
Bakre, Shivani, et al. "Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes." Neurourology and urodynamics vol. 41,1 (2022): 323-331. doi: https://doi.org/10.1002/nau.24823
Bakre S, Holt SK, Oerline M, Braffett BH, Pop-Busui R, Wessells H, Sarma AV. Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes. Neurourol Urodyn. 2022 Jan;41(1):323-331. doi: 10.1002/nau.24823. Epub 2021 Oct 21. PMID: 34672384; PMCID: PMC8738144.
Copy Download .nbib Format: NLM
Share it on

Neurourol Urodyn. 2022 Jan;41(1):323-331. doi: 10.1002/nau.24823. Epub 2021 Oct 21.

Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes.

Neurourology and urodynamics

Shivani Bakre, Sarah K Holt, Mary Oerline, Barbara H Braffett, Rodica Pop-Busui, Hunter Wessells, Aruna V Sarma,

Affiliations

  1. Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.
  2. Department of Urology and Diabetes Research Center, University of Washington, Seattle, Washington, USA.
  3. Biostatistics Center, George Washington University, Rockville, Maryland, USA.
  4. Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.

PMID: 34672384 PMCID: PMC8738144 DOI: 10.1002/nau.24823

Abstract

AIMS: Urinary incontinence (UI) in women is a dynamic condition with numerous risk factors yet most studies have focused on examining its prevalence at a single time. The objective of this study was to describe the long-term time course of UI in women with type 1 diabetes (T1D).

METHODS: Longitudinal data in women with T1D were collected from 568 women in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. Over a 12-year period, participants annually responded to whether they had experienced UI in the past year.

RESULTS: We identified four categories of UI in this population over time: 205 (36.1%) women never reported UI (no UI), 70 (12.3%) reported it one or two consecutive years only (isolated UI), 247 (43.5%) periodically changed status between UI and no UI (intermittent UI), and 46 (8.1%) reported UI continuously after the first report (persistent UI). Compared to women reporting no/isolated UI, women displaying the intermittent phenotype were significantly more likely to be obese (OR: 1.86, 95% CI 1.15, 3.00) and report prior hysterectomy (OR: 2.57, 95% CI: 1.39, 4.77); whereas women with persistent UI were significantly more likely to have abnormal autonomic function (OR: 2.36, 95% CI: 1.16-4.80).

CONCLUSIONS: UI is a dynamic condition in women with T1D. Varying risk factors observed for the different phenotypes of UI suggest distinctive pathophysiological mechanisms. These findings have the potential to be used to guide individualized interventions for UI in women with diabetes.

© 2021 Wiley Periodicals LLC.

Keywords: natural history; type 1 diabetes; urinary incontinence

References

  1. Obstet Gynecol. 2007 Aug;110(2 Pt 1):346-53 - PubMed
  2. Physiol Rev. 2013 Apr;93(2):653-80 - PubMed
  3. N Engl J Med. 2003 Jun 5;348(23):2294-303 - PubMed
  4. Obstet Gynecol. 2008 Feb;111(2 Pt 1):324-31 - PubMed
  5. Diabetes Care. 2006 Feb;29(2):385-90 - PubMed
  6. Eur Urol. 2010 Oct;58(4):532-43 - PubMed
  7. Physiol Rev. 2020 Oct 1;100(4):1621-1705 - PubMed
  8. Diabetologia. 2007 Nov;50(11):2239-44 - PubMed
  9. Diabetes Care. 1999 Jan;22(1):99-111 - PubMed
  10. Diabetes. 1986 May;35(5):530-45 - PubMed
  11. Am J Obstet Gynecol. 2018 May;218(5):502.e1-502.e8 - PubMed
  12. Int Urogynecol J Pelvic Floor Dysfunct. 2000;11(5):301-19 - PubMed
  13. Diabet Med. 2016 Nov;33(11):1528-1535 - PubMed
  14. J Urol. 2009 Dec;182(6 Suppl):S18-26 - PubMed
  15. J Sex Med. 2017 Oct;14(10):1187-1194 - PubMed
  16. Diabetes Care. 2014;37(1):9-16 - PubMed
  17. Lancet. 1998 Sep 12;352(9131):837-53 - PubMed
  18. Urology. 2019 Nov;133S:14-23 - PubMed
  19. J Urol. 2009 Mar;181(3):1224-30; discussion 1230 - PubMed
  20. JAMA. 2014 Jun 11;311(22):2315-25 - PubMed
  21. Kidney Int. 1993 Mar;43(3):668-74 - PubMed
  22. J Urol. 1997 Feb;157(2):580-4 - PubMed
  23. Neurourol Urodyn. 2014 Jun;33(5):597-601 - PubMed
  24. Circulation. 2009 Jun 9;119(22):2886-93 - PubMed
  25. Diabetes. 2020 May;69(5):1000-1010 - PubMed
  26. Biomed Res Int. 2014;2014:865463 - PubMed
  27. Diabetes Care. 2006 Jun;29(6):1307-12 - PubMed
  28. Diabetes Care. 2010 May;33(5):1090-6 - PubMed
  29. Diabetes Care. 2016 Sep;39(9):1587-93 - PubMed
  30. Urology. 2011 Mar;77(3):699-705 - PubMed
  31. Dan Med Bull. 1978 Feb;25(2):49-60 - PubMed
  32. Am J Obstet Gynecol. 2007 Aug;197(2):167.e1-5 - PubMed
  33. Neurourol Urodyn. 2000;19(2):137-45 - PubMed
  34. Int J Gynaecol Obstet. 2003 Sep;82(3):327-38 - PubMed
  35. Diabetes Care. 2018 Oct;41(10):2170-2177 - PubMed
  36. Int Urogynecol J Pelvic Floor Dysfunct. 2000;11(1):41-4 - PubMed

Publication Types

Grant support