Biomol Ther (Seoul). 2022 Jan 01;30(1):1-18. doi: 10.4062/biomolther.2021.102.
Biomolecules & therapeutics
F Peter Guengerich
PMID: 34475272 PMCID: PMC8724836 DOI: 10.4062/biomolther.2021.102
Drug-drug interactions are a major cause of hospitalization and deaths related to drug use. A large fraction of these is due to inhibition of enzymes involved in drug metabolism and transport, particularly cytochrome P450 (P450) enzymes. Understanding basic mechanisms of enzyme inhibition is important, particularly in terms of reversibility and the use of the appropriate parameters. In addition to drug-drug interactions, issues have involved interactions of drugs with foods and natural products related to P450 enzymes. Predicting drug-drug interactions is a major effort in drug development in the pharmaceutical industry and regulatory agencies. With appropriate
Keywords: CYP; Cytochrome P450; Drug-drug interactions; Enzyme inhibition; P450 inhibition