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Watahiki H, Fujii K, Fukagawa T, et al. Frequencies of D19S433 silent alleles in a Japanese population of 1501 individuals and their effect on likelihood ratios calculated in kinship tests. Leg Med (Tokyo). 2021;54:102008doi: 10.1016/j.legalmed.2021.102008.
Watahiki, H., Fujii, K., Fukagawa, T., Mita, Y., Kitayama, T., & Mizuno, N. (2021). Frequencies of D19S433 silent alleles in a Japanese population of 1501 individuals and their effect on likelihood ratios calculated in kinship tests. Legal medicine (Tokyo, Japan), 54102008. https://doi.org/10.1016/j.legalmed.2021.102008
Watahiki, Haruhiko, et al. "Frequencies of D19S433 silent alleles in a Japanese population of 1501 individuals and their effect on likelihood ratios calculated in kinship tests." Legal medicine (Tokyo, Japan) vol. 54 (2021): 102008. doi: https://doi.org/10.1016/j.legalmed.2021.102008
Watahiki H, Fujii K, Fukagawa T, Mita Y, Kitayama T, Mizuno N. Frequencies of D19S433 silent alleles in a Japanese population of 1501 individuals and their effect on likelihood ratios calculated in kinship tests. Leg Med (Tokyo). 2021 Dec 27;54:102008. doi: 10.1016/j.legalmed.2021.102008. Epub 2021 Dec 27. PMID: 34974234.
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Leg Med (Tokyo). 2021 Dec 27;54:102008. doi: 10.1016/j.legalmed.2021.102008. Epub 2021 Dec 27.

Frequencies of D19S433 silent alleles in a Japanese population of 1501 individuals and their effect on likelihood ratios calculated in kinship tests.

Legal medicine (Tokyo, Japan)

Haruhiko Watahiki, Koji Fujii, Takashi Fukagawa, Yusuke Mita, Tetsushi Kitayama, Natsuko Mizuno

Affiliations

  1. National Research Institute of Police Science, 6-3-1 Kashiwanoha Kashiwa, Chiba 277-0882, Japan. Electronic address: [email protected].
  2. National Research Institute of Police Science, 6-3-1 Kashiwanoha Kashiwa, Chiba 277-0882, Japan.

PMID: 34974234 DOI: 10.1016/j.legalmed.2021.102008

Abstract

Although silent alleles in D19S433 typing using the GlobalFiler PCR Amplification Kit have been reported, the exact frequency of the D19S433 silent alleles in population data of 1501 Japanese individuals, which are widely used for the assessment of Japanese STR typing results, is unclear. In this study, we examined the exact D19S433 silent allele frequency in this population data. We newly observed the G32A variant causing silent alleles at D19S433 in five samples. Combining them with data including 30 samples with the variant reported previously, we determined that the total frequency of the silent alleles (i.e. the frequency of the G32A variant) in the 1501 Japanese samples was 0.0117 (35/3002). Using the D19S433 allele frequency data, we evaluated the effect of presence/absence information for the D19S433 silent allele on kinship tests. Likelihood ratios (LRs) were calculated for both simulated parent-child and full sibling cases, revealing that the LR may change by approximately 10

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: D19S433; GlobalFiler; Japanese population; Kinship test; Likelihood ratio; Silent allele

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