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Ferreira CS, Vendramini THA, Amaral AR, et al. Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan. BMC Vet Res. 2022;18(1):14doi: 10.1186/s12917-021-03106-2.
Ferreira, C. S., Vendramini, T. H. A., Amaral, A. R., Rentas, M. F., Ernandes, M. C., da Silva, F. L., Oba, P. M., de Oliveira Roberti Filho, F., & Brunetto, M. A. (2022). Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan. BMC veterinary research, 18(1), 14. https://doi.org/10.1186/s12917-021-03106-2
Ferreira, Chayanne Silva, et al. "Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan." BMC veterinary research vol. 18,1 (2022): 14. doi: https://doi.org/10.1186/s12917-021-03106-2
Ferreira CS, Vendramini THA, Amaral AR, Rentas MF, Ernandes MC, da Silva FL, Oba PM, de Oliveira Roberti Filho F, Brunetto MA. Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan. BMC Vet Res. 2022 Jan 03;18(1):14. doi: 10.1186/s12917-021-03106-2. PMID: 34980115; PMCID: PMC8722019.
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BMC Vet Res. 2022 Jan 03;18(1):14. doi: 10.1186/s12917-021-03106-2.

Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan.

BMC veterinary research

Chayanne Silva Ferreira, Thiago Henrique Annibale Vendramini, Andressa Rodrigues Amaral, Mariana Fragoso Rentas, Mariane Ceschin Ernandes, Flavio Lopes da Silva, Patricia Massae Oba, Fernando de Oliveira Roberti Filho, Marcio Antonio Brunetto

Affiliations

  1. Rio Verde University, Fazenda Fontes do Saber, PO Box 104, Rio Verde, Goiás, 75901-970, Brazil.
  2. Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of São Paulo, 87, Prof. Orlando Marques de Paiva Ave, São Paulo, São Paulo, 05508270, Brazil.
  3. Grandfood Industria e Comercio LTDA, Luiz Augusto de Oliveira Hwy, km 204, Dourado, São Paulo, 13590-000, Brazil.
  4. Biorigin, Lençóis Paulista, São Paulo, Brazil.
  5. Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of São Paulo, 87, Prof. Orlando Marques de Paiva Ave, São Paulo, São Paulo, 05508270, Brazil. [email protected].

PMID: 34980115 PMCID: PMC8722019 DOI: 10.1186/s12917-021-03106-2

Abstract

BACKGROUND: Obesity is one of the most common nutritional disorders in dogs and cats and is related to the development metabolic comorbidities. Weight loss is the recommended treatment, but success is difficult due to the poor satiety control. Yeast beta-glucans are known as biological modifiers because of their innumerable functions reported in studies with mice and humans, but only one study with dogs was found. This study aimed to evaluate the effects of a diet supplemented with 0.1% beta-glucan on glucose, lipid homeostasis, inflammatory cytokines and satiety parameters in obese dogs. Fourteen dogs composed three experimental groups: Obese group (OG) with seven dogs with body condition score (BCS) 8 or 9; Lean group (LG) included seven non-obese dogs with a BCS of 5; and Supplemented Obese group (SOG) was the OG dogs after 90 days of consumption of the experimental diet.

RESULTS: Compared to OG, SOG had lower plasma basal glycemic values (p = 0.05) and reduced serum cholesterol and triglyceride levels. TNF-α was lower in SOG than in OG (p = 0.05), and GLP-1 was increased in SOG compared to OG and LG (p = 0.02).

CONCLUSION: These results are novel and important for recognizing the possibility of using beta-glucan in obesity prevention and treatment.

© 2021. The Author(s).

Keywords: beta-glucan; canine; cholesterol; triglycerides; weight loss

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