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Zhvania MG, Japaridze N, Tizabi Y, et al. Age-related cognitive decline in rats is sex and context dependent. Neurosci Lett. 2021;765:136262doi: 10.1016/j.neulet.2021.136262.
Zhvania, M. G., Japaridze, N., Tizabi, Y., Lomidze, N., Pochkhidze, N., & Lordkipanidze, T. (2021). Age-related cognitive decline in rats is sex and context dependent. Neuroscience letters, 765136262. https://doi.org/10.1016/j.neulet.2021.136262
Zhvania, Mzia G, et al. "Age-related cognitive decline in rats is sex and context dependent." Neuroscience letters vol. 765 (2021): 136262. doi: https://doi.org/10.1016/j.neulet.2021.136262
Zhvania MG, Japaridze N, Tizabi Y, Lomidze N, Pochkhidze N, Lordkipanidze T. Age-related cognitive decline in rats is sex and context dependent. Neurosci Lett. 2021 Nov 20;765:136262. doi: 10.1016/j.neulet.2021.136262. Epub 2021 Sep 21. PMID: 34560192.
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Neurosci Lett. 2021 Nov 20;765:136262. doi: 10.1016/j.neulet.2021.136262. Epub 2021 Sep 21.

Age-related cognitive decline in rats is sex and context dependent.

Neuroscience letters

Mzia G Zhvania, Nadezhda Japaridze, Yousef Tizabi, Nino Lomidze, Nino Pochkhidze, Tamar Lordkipanidze

Affiliations

  1. School of Natural Sciences and Medicine, Ilia State University, 3/5 K/Cholokashvili Avenue, 0162 Tbilisi, Georgia; Department of Neuron Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 9160 Tbilisi, Georgia. Electronic address: [email protected].
  2. Department of Neuron Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 9160 Tbilisi, Georgia; School of Medicine, New Vision University, 1A Evgeni Mikeladze Street, 0159 Tbilisi, Georgia.
  3. Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA.
  4. School of Natural Sciences and Medicine, Ilia State University, 3/5 K/Cholokashvili Avenue, 0162 Tbilisi, Georgia.
  5. School of Natural Sciences and Medicine, Ilia State University, 3/5 K/Cholokashvili Avenue, 0162 Tbilisi, Georgia; Department of Neuron Ultrastructure and Nanoarchitecture, Ivane Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 9160 Tbilisi, Georgia.

PMID: 34560192 DOI: 10.1016/j.neulet.2021.136262

Abstract

Previously, we had observed age-related cognitive decline in male rats compared to adolescent and adult rats. This was shown in both a multi-branched maze test (MBM), as well as in the Morris water maze test (MWM). In the present study, we compared the behavior of similar age groups in both male and female rats using the same paradigms. The results confirmed the increase in errors and time spent in MBM in aged male rats compared to other age groups. However, no such differences were observed in female rats. In the acquisition phase of MWM, aged male rats did not differ significantly from the other two groups in terms of time spent in quadrants, whereas aged female rats spent significantly more time in quadrants compared to the other 2 age groups. Aged male rats also travelled significantly more than the other 2 age groups during the acquisition phase, whereas no such differences were observed in female rats. In both short term (30 min post acquisition) and long term (24 h after acquisition) retrieval phases of MWM, significant gender-related differences were also observed in all age groups. These findings suggest gender- and context-dependent alterations in cognitive functions during aging.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Aging; Cognition; Male and female rats; Morris water maze; Multi branch maze

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