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Su C, Hoffman KL, Xu Z, et al. Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome. Crit Care Explor. 2021;3(12):e0589doi: 10.1097/CCE.0000000000000589.
Su, C., Hoffman, K. L., Xu, Z., Sanchez, E., Siempos, I. I., Harrington, J. S., Racanelli, A. C., Plataki, M., Wang, F., & Schenck, E. J. (2021). Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome. Critical care explorations, 3(12), e0589. https://doi.org/10.1097/CCE.0000000000000589
Su, Chang, et al. "Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome." Critical care explorations vol. 3,12 (2021): e0589. doi: https://doi.org/10.1097/CCE.0000000000000589
Su C, Hoffman KL, Xu Z, Sanchez E, Siempos II, Harrington JS, Racanelli AC, Plataki M, Wang F, Schenck EJ. Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome. Crit Care Explor. 2021 Dec 02;3(12):e0589. doi: 10.1097/CCE.0000000000000589. eCollection 2021 Dec. PMID: 34984341; PMCID: PMC8718234.
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Crit Care Explor. 2021 Dec 02;3(12):e0589. doi: 10.1097/CCE.0000000000000589. eCollection 2021 Dec.

Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome.

Critical care explorations

Chang Su, Katherine L Hoffman, Zhenxing Xu, Elizabeth Sanchez, Ilias I Siempos, John S Harrington, Alexandra C Racanelli, Maria Plataki, Fei Wang, Edward J Schenck

Affiliations

  1. Department of Health Service Administration and Policy, College of Public Health, Temple University, Philadelphia, PA.
  2. Department of Population Health Sciences, Weill Cornell Medicine, New York, NY.
  3. Department of Medicine, New York-Presbyterian Hospital-Weill Cornell Medical Center, Weill Cornell Medicine, New York, NY.
  4. Division of Pulmonary & Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY.
  5. First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

PMID: 34984341 PMCID: PMC8718234 DOI: 10.1097/CCE.0000000000000589

Abstract

OBJECTIVES: This report aims to characterize the kinetics of serum albumin in critically ill patients with coronavirus disease 2019 compared with critically ill patients with sepsis-induced acute respiratory distress syndrome.

DESIGN: Retrospective analysis.

SETTING: We analyzed two critically ill cohorts, one with coronavirus disease 2019 and another with sepsis-induced acute respiratory distress syndrome, treated in the New York Presbyterian Hospital-Weill Cornell Medical Center.

PATIENTS: Adult patients in the coronavirus disease 2019 cohort, diagnosed through reverse transcriptase-polymerase chain reaction assays performed on nasopharyngeal swabs, were admitted from March 3, 2020, to July 10, 2020. Adult patients in the sepsis-induced acute respiratory distress syndrome cohort, defined by Sepsis III criteria receipt of invasive mechanical ventilation and a Pao

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: We evaluated serial serum albumin levels within 30 days after ICU admission in each cohort. We then examined the albumin progression trajectories, aligned at ICU admission time to test the relationship at a similar point in disease progression, in survivors and nonsurvivors. Albumin trajectory in all critically ill coronavirus disease 2019 patients show two distinct phases: phase I (deterioration) showing rapid albumin loss and phase II (recovery) showing albumin stabilization or improvement. Meanwhile, albumin recovery predicted clinical improvement in critical coronavirus disease 2019. In addition, we found a deterioration and recovery trends in survivors in the sepsis-induced acute respiratory distress syndrome cohort but did not find such two-phase trend in nonsurvivors.

CONCLUSIONS: The changes in albumin associated with coronavirus disease 2019 associated respiratory failure are transient compared with sepsis-associated acute respiratory distress syndrome and highlight the potential for recovery following a protracted course of severe coronavirus disease 2019.

Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

Keywords: acute respiratory distress syndrome; albumin; coronavirus disease 2019; sepsis

Conflict of interest statement

Dr. Wang is supported by National Science Foundation-Information and Intelligent Systems 2027970, 1750326, Office of Naval Research N00014-18-1-2585. The remaining authors have disclosed that they do

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