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Arch Pediatr. 2022 Jan;29(1):1-11. doi: 10.1016/j.arcped.2021.09.009. Epub 2021 Nov 08.

The role of nutrition in non-alcoholic fatty liver disease treatment in obese children.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

D Guimber, D Debray, A Bocquet, A Briend, J-P Chouraqui, D Darmaun, F Feillet, M-L Frelut, R Hankard, A Lapillonne, N Peretti, J-C Rozé, U Simeoni, D Turck, C Dupont, Comité de Nutrition de la Société Française de Pédiatrie Cnsfp

Affiliations

  1. Université de Lille, 59000 Lille, France. Electronic address: [email protected].
  2. Université Paris Descartes, 75006 Paris, France, Groupe Francophone d'Hépatologie Gastroentérologie Nutrition Pédiatrique (GFHGNP).
  3. Université de Franche-Comté, 25000 Besançon, France.
  4. Institut de recherche pour le développement, 13002 Marseille, France.
  5. Université de Lausanne, 1011 Lausanne, Switzerland.
  6. Université Nantes-Atlantique, 44300 Nantes, France.
  7. Université de Lorraine, 54000 Nancy, France.
  8. Albi, 81000 France.
  9. Université de Tours, 37000 Tours, France.
  10. Université de Lyon, 69000 Lyon, France.
  11. Université de Lille, 59000 Lille, France.
  12. Hôpital Necker - Enfants-Malades (NEM), 149, rue de Sèvres, 75015 Paris.

PMID: 34758930 DOI: 10.1016/j.arcped.2021.09.009

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs mostly in the context of insulin resistance and obesity. It has rapidly evolved into the most common cause of liver disease among children. The incidence is high in obese children and a greater risk of disease progression is associated with severe obesity, highlighting the role of nutrition. To date, there is no consensus on NAFLD management. This is a narrative review of clinical studies on the potential benefit of nutritional interventions, including lifestyle modifications, vitamins, docosahexaenoic acid, and probiotics in children with NAFLD. The Comité de nutrition de la Société Française de Pédiatrie (CN-SFP) emphasizes the effect of limiting added sugar intake, i.e., fructose or sucrose-containing beverages, and promoting physical activity in the care of NAFLD.

Copyright © 2021. Published by Elsevier Masson SAS.

Keywords: Dietary intervention; Non-alcoholic fatty liver disease; Omega-3 fatty acid; Probiotic; Steatosis; vitamin E

Conflict of interest statement

Conflicts of interests The author and co-authors have no conflicts of interest to declare

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