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Wang L, Wang B, Gasek NS, et al. Targeting p21. Cell Metab. 2021;34(1):75-89.e8doi: 10.1016/j.cmet.2021.11.002.
Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., Kim, T., Prata, L. G. P. L., Palmer, A. K., Li, M., Inman, C. L., Barber, L. S., Al-Naggar, I. M. A., Zhou, Y., Du, W., Kshitiz, Kuchel, G. A., Meves, A., Tchkonia, T., Kirkland, J. L., Robson, P., & Xu, M. (2022). Targeting p21. Cell metabolism, 34(1), 75-89.e8. https://doi.org/10.1016/j.cmet.2021.11.002
Wang, Lichao, et al. "Targeting p21." Cell metabolism vol. 34,1 (2022): 75-89.e8. doi: https://doi.org/10.1016/j.cmet.2021.11.002
Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21. Cell Metab. 2022 Jan 04;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22. PMID: 34813734; PMCID: PMC8732323.
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Cell Metab. 2022 Jan 04;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22.

Targeting p21.

Cell metabolism

Lichao Wang, Binsheng Wang, Nathan S Gasek, Yueying Zhou, Rachel L Cohn, Dominique E Martin, Wulin Zuo, William F Flynn, Chun Guo, Evan R Jellison, Taewan Kim, Larissa G P Langhi Prata, Allyson K Palmer, Ming Li, Christina L Inman, Lauren S Barber, Iman M A Al-Naggar, Yanjiao Zhou, Wenqiang Du, Kshitiz, George A Kuchel, Alexander Meves, Tamar Tchkonia, James L Kirkland, Paul Robson, Ming Xu

Affiliations

  1. UConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
  2. Xiangya Stomatological Hospital, Central South University, Changsha, 86-410000, China; Center for Regenerative Medicine and Skeletal Development, UConn Health, Farmington, CT 06030, USA.
  3. UConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Biomedical Science Graduate Program, UConn Health, Farmington, CT 06030, USA.
  4. The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.
  5. UConn Center on Aging, UConn Health, Farmington, CT 06030, USA.
  6. Department of Immunology, UConn Health, Farmington, CT 06030, USA.
  7. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
  8. Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
  9. Department of Medicine, UConn Health, Farmington, CT 06030, USA.
  10. Department of Biomedical Engineering, UConn Health, Farmington, CT 06030, USA.
  11. Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.
  12. UConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA. Electronic address: [email protected].

PMID: 34813734 PMCID: PMC8732323 DOI: 10.1016/j.cmet.2021.11.002

Abstract

Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin resistance. Here, using single-cell transcriptomics, we identify a small, critically important, but previously unexamined cell population, p21

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Cellular senescence; NF-κB; diabetes; fat transplantation; senolytics; xenograft

Conflict of interest statement

Declaration of interests M.X., A.K.P., T.T., and J.L.K. have a financial interest related to this research. Patents on senolytic drugs (including PCT/US2016/041646, filed at the US Patent Office) are

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