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Taytard J, Gand C, Niérat MC, et al. Impact of inspiratory threshold loading on brain activity and cognitive performances in healthy humans. J Appl Physiol (1985). 2021;132(1):95-105doi: 10.1152/japplphysiol.00994.2020.
Taytard, J., Gand, C., Niérat, M. C., Barthes, R., Lavault, S., Adler, D., Morélot-Panzini, C., Gatignol, P., Campion, S., Serresse, L., Wattiez, N., Straus, C., & Similowski, T. (2022). Impact of inspiratory threshold loading on brain activity and cognitive performances in healthy humans. Journal of applied physiology (Bethesda, Md. : 1985), 132(1), 95-105. https://doi.org/10.1152/japplphysiol.00994.2020
Taytard, Jessica, et al. "Impact of inspiratory threshold loading on brain activity and cognitive performances in healthy humans." Journal of applied physiology (Bethesda, Md. : 1985) vol. 132,1 (2022): 95-105. doi: https://doi.org/10.1152/japplphysiol.00994.2020
Taytard J, Gand C, Niérat MC, Barthes R, Lavault S, Adler D, Morélot-Panzini C, Gatignol P, Campion S, Serresse L, Wattiez N, Straus C, Similowski T. Impact of inspiratory threshold loading on brain activity and cognitive performances in healthy humans. J Appl Physiol (1985). 2022 Jan 01;132(1):95-105. doi: 10.1152/japplphysiol.00994.2020. Epub 2021 Nov 24. PMID: 34818073.
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J Appl Physiol (1985). 2022 Jan 01;132(1):95-105. doi: 10.1152/japplphysiol.00994.2020. Epub 2021 Nov 24.

Impact of inspiratory threshold loading on brain activity and cognitive performances in healthy humans.

Journal of applied physiology (Bethesda, Md. : 1985)

Jessica Taytard, Camille Gand, Marie-Cécile Niérat, Romain Barthes, Sophie Lavault, Dan Adler, Capucine Morélot-Panzini, Peggy Gatignol, Sebastien Campion, Laure Serresse, Nicolas Wattiez, Christian Straus, Thomas Similowski

Affiliations

  1. Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005 Paris, France.
  2. AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Armand-Trousseau, Service de Pneumologie Pédiatrique, F-75012 Paris, France.
  3. AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service de Pneumologie, Médecine Intensive et Réanimation (Département R3S), F-75013 Paris, France.
  4. Division of Pulmonary Disease, Department of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
  5. Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  6. AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service d'ORL et d'oto-neurochirurgie, F-75013 Paris, France.
  7. AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Département d'Anesthésie-Réanimation, F-75013 Paris, France.
  8. AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Unité Mobile de Soins Palliatifs, F-75013 Paris, France.
  9. AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service d'Exploration Fonctionnelles de la Respiration, de l'Exercice et de la Dyspnée (Département R3S), F-75013 Paris, France.

PMID: 34818073 DOI: 10.1152/japplphysiol.00994.2020

Abstract

In healthy humans, inspiratory threshold loading deteriorates cognitive performances. This can result from motor-cognitive interference (activation of motor respiratory-related cortical networks vs. executive resources allocation), sensory-cognitive interference (dyspnea vs. shift in attentional focus), or both. We hypothesized that inspiratory loading would concomitantly induce dyspnea, activate motor respiratory-related cortical networks, and deteriorate cognitive performance. We reasoned that a concomitant activation of cortical networks and cognitive deterioration would be compatible with motor-cognitive interference, particularly in case of a predominant alteration of executive cognitive performances. Symmetrically, we reasoned that a predominant alteration of attention-depending performances would suggest sensory-cognitive interference. Twenty-five volunteers (12 men; 19.5-51.5 yr) performed the Paced Auditory Serial Addition Test (PASAT-A and B; calculation capacity, working memory, attention), the Trail Making Test (TMT-A, visuospatial exploration capacity; TMT-B, visuospatial exploration capacity, and attention), and the Corsi block-tapping test (visuospatial memory, short-term, and working memory) during unloaded breathing and inspiratory threshold loading in random order. Loading consistently induced dyspnea and respiratory-related brain activation. It was associated with deteriorations in PASAT-A [52 [45.5;55.5]; (median [interquartile range]) to 48 [41;54.5],

Keywords: cognitive performance; control of breathing; dyspnea; electroencephalogram; inspiratory loading

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