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Nevejan L, Strypens T, Van Nieuwenhove M, et al. Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types. Clin Chim Acta. 2021;525:54-61doi: 10.1016/j.cca.2021.12.011.
Nevejan, L., Strypens, T., Van Nieuwenhove, M., Boel, A., Cattoir, L., Meeus, P., Bossuyt, X., De Neve, N., & Van Hoovels, L. (2022). Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types. Clinica chimica acta; international journal of clinical chemistry, 52554-61. https://doi.org/10.1016/j.cca.2021.12.011
Nevejan, Louis, et al. "Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types." Clinica chimica acta; international journal of clinical chemistry vol. 525 (2022): 54-61. doi: https://doi.org/10.1016/j.cca.2021.12.011
Nevejan L, Strypens T, Van Nieuwenhove M, Boel A, Cattoir L, Meeus P, Bossuyt X, De Neve N, Van Hoovels L. Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types. Clin Chim Acta. 2022 Jan 15;525:54-61. doi: 10.1016/j.cca.2021.12.011. Epub 2021 Dec 14. PMID: 34919937; PMCID: PMC8669946.
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Clin Chim Acta. 2022 Jan 15;525:54-61. doi: 10.1016/j.cca.2021.12.011. Epub 2021 Dec 14.

Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types.

Clinica chimica acta; international journal of clinical chemistry

Louis Nevejan, Thomas Strypens, Mathias Van Nieuwenhove, An Boel, Lien Cattoir, Peter Meeus, Xavier Bossuyt, Nikolaas De Neve, Lieve Van Hoovels

Affiliations

  1. Department of Laboratory Medicine, OLV Hospital, Aalst, Belgium; Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium.
  2. Department of Intensive Care Medicine, OLV Hospital, Aalst, Belgium; Department of Anesthesiology, OLV Hospital, Aalst, Belgium.
  3. Department of Laboratory Medicine, OLV Hospital, Aalst, Belgium.
  4. Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
  5. Department of Laboratory Medicine, OLV Hospital, Aalst, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. Electronic address: [email protected].

PMID: 34919937 PMCID: PMC8669946 DOI: 10.1016/j.cca.2021.12.011

Abstract

INTRODUCTION: During the recent SARS-CoV-2 pandemic, circulating calprotectin (cCLP) gained interest as biomarker to predict the severity of COVID-19. We aimed to investigate the prognostic value of cCLP measured in serum, heparin, EDTA and citrate plasma.

MATERIALS AND METHODS: COVID-19 patients were prospectively included, in parallel with two SARS-CoV-2 negative control populations. The prognostic value of cCLP was compared with IL-6, CRP, LDH, procalcitonin, and the 4C-mortality score by AUROC analysis.

RESULTS: For the 136 COVID-19 patients, cCLP levels were higher compared to the respective control populations, with significantly higher cCLP levels in serum and heparin than in EDTA or citrate. Higher cCLP levels were obtained for COVID-19 patients with i) severe/critical illness (n = 70), ii) ICU admission (n = 66) and iii) need for mechanical ventilation/ECMO (n = 25), but iv) not in patients who deceased within 30 days (n = 41). The highest discriminatory power (AUC [95% CI]) for each defined outcome was i) CRP (0.835 [0.755-0.914]); ii) EDTA cCLP (0.780 [0.688-0.873]); iii) EDTA cCLP (0.842 [0.758-0.925]) and iv) the 4C-mortality score (0.713 [0.608-0.818]).

CONCLUSION: Measuring cCLP in COVID-19 patients helps the clinician to predict the clinical course of COVID-19. The discriminatory power of EDTA and citrate plasma cCLP levels often outperforms heparin plasma cCLP levels.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: COVID-19; Calprotectin; Plasma; Pre-analytics; Prognostic value; Serum

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