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Bourgeois-Vionnet J, Ryvlin P, Elsensohn MH, et al. Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy. Epilepsy Behav. 2021;126:108486doi: 10.1016/j.yebeh.2021.108486.
Bourgeois-Vionnet, J., Ryvlin, P., Elsensohn, M. H., Michel, V., Valton, L., Derambure, P., Frazzini, V., Hirsch, E., Maillard, L., Bartolomei, F., Biberon, J., Petit, J., Biraben, A., Crespel, A., Thomas, P., Lemesle-Martin, M., Convers, P., Leclercq, M., Boulogne, S., Roy, P., Rheims, S. (2022). Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy. Epilepsy & behavior : E&B, 126108486. https://doi.org/10.1016/j.yebeh.2021.108486
Bourgeois-Vionnet, Julie, et al. "Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy." Epilepsy & behavior : E&B vol. 126 (2022): 108486. doi: https://doi.org/10.1016/j.yebeh.2021.108486
Bourgeois-Vionnet J, Ryvlin P, Elsensohn MH, Michel V, Valton L, Derambure P, Frazzini V, Hirsch E, Maillard L, Bartolomei F, Biberon J, Petit J, Biraben A, Crespel A, Thomas P, Lemesle-Martin M, Convers P, Leclercq M, Boulogne S, Roy P, Rheims S. Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy. Epilepsy Behav. 2022 Jan;126:108486. doi: 10.1016/j.yebeh.2021.108486. Epub 2021 Dec 18. PMID: 34929474.
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Epilepsy Behav. 2022 Jan;126:108486. doi: 10.1016/j.yebeh.2021.108486. Epub 2021 Dec 18.

Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy.

Epilepsy & behavior : E&B

Julie Bourgeois-Vionnet, Philippe Ryvlin, Mad-Hélénie Elsensohn, Véronique Michel, Luc Valton, Philippe Derambure, Valerio Frazzini, Edouard Hirsch, Louis Maillard, Fabrice Bartolomei, Julien Biberon, Jerôme Petit, Arnaud Biraben, Arielle Crespel, Pierre Thomas, Martine Lemesle-Martin, Philippe Convers, Mathilde Leclercq, Sébastien Boulogne, Pascal Roy, Sylvain Rheims,

Affiliations

  1. Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France.
  2. Department of Clinical Neurosciences, Centre Hospitalo-Universitaire Vaudois, Lausanne, Switzerland.
  3. Lyon University, Lyon, France; Équipe Biostatistique Santé, Laboratoire de Biométrie et Biologie Évolutive, CNRS UMR 5558, Villeurbanne, France; Service de Biostatistique-Bioinformatique, Pôle Santé Publique, Hospices Civils de Lyon, Lyon, France.
  4. Department of Neurology, Hôpital Pellegrin, Bordeaux, France.
  5. Clinical Neurophysiology, Department of Neurology, University Hospital of Toulouse, CerCO CNRS UMR 5549, University of Toulouse, France.
  6. Department of Clinical Neurophysiology, Lille University Medical Center, EA 1046, University of Lille 2, France.
  7. Epileptology Unit, Assistance Publique-Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière and Brain and Spine Institute (ICM; INSERM UMRS1127, CNRS UMR7225, UPMC University Paris 06), Paris, France.
  8. Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.
  9. Neurology Department, University Hospital of Nancy, Nancy, France.
  10. Clinical Neurophysiology and Epileptology Department, Timone Hospital, Marseille, France.
  11. Department of Clinical Neurophysiology, INSERM U930, University Hospital of Tours, Tours, France.
  12. La Teppe Epilepsy Center, Tain l'Hermitage, France.
  13. Department of Neurology, University Hospital of Rennes, Rennes, France.
  14. Epilepsy Unit, Montpellier, France.
  15. Neurology Department University Hospitals of Nice, Nice, France.
  16. Department of Clinical Neurophysiology, University Hospital of Dijon, Dijon, France.
  17. Department of Neurology, University Hospital of Saint-Etienne, Saint-Etienne, France.
  18. Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France; Lyon's Neuroscience Research Center, INSERM U1028 / CNRS UMR 5292 and Lyon 1 University, Lyon, France.
  19. Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France; Lyon's Neuroscience Research Center, INSERM U1028 / CNRS UMR 5292 and Lyon 1 University, Lyon, France; Epilepsy Institute, Lyon, France. Electronic address: [email protected].

PMID: 34929474 DOI: 10.1016/j.yebeh.2021.108486

Abstract

OBJECTIVE: To assess the relation between coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy.

METHODS: Cross-sectional analysis of data collected in the SAVE study, which included patients with drug-resistant focal epilepsy during long-term EEG monitoring. Patients in whom both coffee consumption and data about seizure frequency, including focal to bilateral tonic-clonic seizures (FBTCS), were available were selected. Coffee consumption was collected using a standardized self-report questionnaire and classified into four groups: none, rare (from less than 1 cup/week to up 3 cups/week), moderate (from 4 cups/week to 3 cups/day), and high (more than 4 cups/day).

RESULTS: Six hundred and nineteen patients were included. There was no relation between coffee consumption and total seizure frequency (p = 0.902). In contrast, the number of FBTCS reported over the past year was significantly associated with usual coffee consumption (p = 0.029). Specifically, number of FBCTS in patients who reported moderate coffee consumption was lower than in others. In comparison with patients with moderate coffee consumption, the odds ratio (95%CI) for reporting at least 1 FBTCS per year was 1.6 (1.03-2.49) in patients who never take coffee, 1.62 (1.02-2.57) in those with rare consumption and 2.05 (1.24-3.4) in those with high consumption. Multiple ordinal logistic regression showed a trend toward an association between coffee consumption and number of FBTCS (p = 0.08).

CONCLUSIONS AND RELEVANCE: Our data suggest that effect of coffee consumption on seizures might depend on dose with potential benefits on FBTCS frequency at moderate doses. These results will have to be confirmed by prospective studies.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Caffeine; Epilepsy; Generalized seizures; Seizures

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