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Mb M, Macoveanu J, Gm K, et al. Influence of pre-treatment structural brain measures on effects of action-based cognitive remediation on executive function in partially or fully remitted patients with bipolar disorder. Eur Neuropsychopharmacol. 2021;56:50-59doi: 10.1016/j.euroneuro.2021.11.010.
Mb, M., Macoveanu, J., Gm, K., Cv, O., & Kw, M. (2021). Influence of pre-treatment structural brain measures on effects of action-based cognitive remediation on executive function in partially or fully remitted patients with bipolar disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 5650-59. https://doi.org/10.1016/j.euroneuro.2021.11.010
Mb, Mogensen, et al. "Influence of pre-treatment structural brain measures on effects of action-based cognitive remediation on executive function in partially or fully remitted patients with bipolar disorder." European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol. 56 (2021): 50-59. doi: https://doi.org/10.1016/j.euroneuro.2021.11.010
Mb M, Macoveanu J, Gm K, Cv O, Kw M. Influence of pre-treatment structural brain measures on effects of action-based cognitive remediation on executive function in partially or fully remitted patients with bipolar disorder. Eur Neuropsychopharmacol. 2021 Dec 18;56:50-59. doi: 10.1016/j.euroneuro.2021.11.010. Epub 2021 Dec 18. PMID: 34933219.
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Eur Neuropsychopharmacol. 2021 Dec 18;56:50-59. doi: 10.1016/j.euroneuro.2021.11.010. Epub 2021 Dec 18.

Influence of pre-treatment structural brain measures on effects of action-based cognitive remediation on executive function in partially or fully remitted patients with bipolar disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

Mogensen Mb, J Macoveanu, Knudsen Gm, Ott Cv, Miskowiak Kw

Affiliations

  1. Neurocognition and Emotion in Affective Disorder (NEAD) Group, Copenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University hospital, Rigshospitalet, Denmark.
  2. Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  3. Neurocognition and Emotion in Affective Disorder (NEAD) Group, Copenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University hospital, Rigshospitalet, Denmark; Department of Psychology, University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected].

PMID: 34933219 DOI: 10.1016/j.euroneuro.2021.11.010

Abstract

Cognitive impairment is an emerging treatment target in patients with bipolar disorder (BD) but so far, no evidence-based treatment options are available. Recent studies indicate promising effects of Cognitive Remediation (CR) interventions, but it is unclear who responds most to these interventions. This report aimed to investigate whether pre-treatment dorsal prefrontal cortex (dPFC) thickness predicts improvement of executive function in response to Action-Based Cognitive Remediation (ABCR) in patients with BD. Complete baseline magnetic resonance imaging (MRI) data were available from 45 partially or fully remitted patients with BD from our randomized controlled ABCR trial (ABCR: n = 25, control group: n = 20). We performed cortical reconstruction and volumetric segmentation using FreeSurfer. Multiple linear regression analysis was conducted to assess the influence of dPFC thickness on ABCR-related executive function improvement, reflected by change in the One Touch Stocking of Cambridge performance from baseline to post-treatment. We also conducted whole brain vertex wise analysis for exploratory purposes. Groups were well-matched for demographic and clinical variables. Less pre-treatment dPFC thickness was associated with greater effect of ABCR on executive function (p = 0.02). Further, whole-brain vertex analysis revealed an association between smaller pre-treatment superior temporal gyrus volume and greater ABCR-related executive function improvement. The observed associations suggest that structural abnormalities in dPFC and superior temporal gyrus are key neurocircuitry treatment targets for CR interventions that target impaired executive function in BD.

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Keywords: Bipolar disorder; Cognitive impairment; Cognitive remediation; Dorsal prefrontal cortex; Randomized controlled trial; structural MRI

Conflict of interest statement

Conflict of interest KWM has received honoraria from Janssen-Cilag and Lundbeck in the past three years. MBM, JM, CVO and GMK report no conflicts of interest.

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