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Kamogawa M, Ikegaya N, Miyake Y, et al. Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma. Surg Neurol Int. 2021;12:614doi: 10.25259/SNI_1120_2021.
Kamogawa, M., Ikegaya, N., Miyake, Y., Hayashi, T., Murata, H., Tateishi, K., & Yamamoto, T. (2021). Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma. Surgical neurology international, 12614. https://doi.org/10.25259/SNI_1120_2021
Kamogawa, Misaki, et al. "Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma." Surgical neurology international vol. 12 (2021): 614. doi: https://doi.org/10.25259/SNI_1120_2021
Kamogawa M, Ikegaya N, Miyake Y, Hayashi T, Murata H, Tateishi K, Yamamoto T. Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma. Surg Neurol Int. 2021 Dec 14;12:614. doi: 10.25259/SNI_1120_2021. eCollection 2021. PMID: 34992930; PMCID: PMC8720448.
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Surg Neurol Int. 2021 Dec 14;12:614. doi: 10.25259/SNI_1120_2021. eCollection 2021.

Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma.

Surgical neurology international

Misaki Kamogawa, Naoki Ikegaya, Yohei Miyake, Takahiro Hayashi, Hidetoshi Murata, Kensuke Tateishi, Tetsuya Yamamoto

Affiliations

  1. Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

PMID: 34992930 PMCID: PMC8720448 DOI: 10.25259/SNI_1120_2021

Abstract

BACKGROUND: Nonconvulsive status epilepticus (NCSE) is induced by common neurosurgical conditions, for example, trauma, stroke, tumors, and surgical interventions in the brain. The aggressiveness of the treatment for NCSE depends on its neurological prognosis. Aphasic status epilepticus (ASE) is a subtype of focal NCSE without consciousness impairment. The impact of ASE on neurological prognosis is poorly documented. We describe a case of postoperative ASE resulting in verbal and memory deficits.

CASE DESCRIPTION: A 54-year-old, right-handed man with focal impaired awareness seizures underwent partial resection for a left temporal lobe tumor. No neurological deficits were observed immediately after surgery. Three days later, however, a focal to bilateral tonic-clonic seizure (FBTCS) occurred, followed by aphasia. Electroencephalography revealed 1.5 Hz left-sided periodic discharges. He was diagnosed with ASE. Multiple anti-seizure drugs were ineffective for the resolution of the patient's verbal disturbance. Nine days after the FBTCS, deep sedation with intravenous anesthetics was performed and the ASE stopped. Thereafter, his symptoms gradually improved. However, the prolonged ASE resulted in verbal and memory deficits. Automated hippocampal volumetry revealed an approximate decrease of 20% on the diseased side on magnetic resonance imaging 3 months after surgery.

CONCLUSION: Prolonged ASE can induce verbal and memory deficits. Early intervention with intravenous anesthetics is required to obtain a favorable neurological prognosis.

Copyright: © 2021 Surgical Neurology International.

Keywords: Aphasic status epilepticus; Intravenous anesthetics; Memory disturbance; Nonconvulsive status epilepticus; Verbal deficit

Conflict of interest statement

There are no conflicts of interest.

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