Display options
Cite
Tuter G, Yildirim AZ, Duman AN, et al. Effects of smoking on the bone alkaline phosphatase in peri-implant crevicular fluid and implant stability quotient around implants before loading. Odontology. 2022;doi: 10.1007/s10266-021-00685-2.
Tuter, G., Yildirim, A. Z., Duman, A. N., Aliyev, B., Atak-Yucel, A., Oruklu, N., & Kivrak, E. (2022). Effects of smoking on the bone alkaline phosphatase in peri-implant crevicular fluid and implant stability quotient around implants before loading. Odontology, . https://doi.org/10.1007/s10266-021-00685-2
Tuter, Gulay, et al. "Effects of smoking on the bone alkaline phosphatase in peri-implant crevicular fluid and implant stability quotient around implants before loading." Odontology vol. (2022). doi: https://doi.org/10.1007/s10266-021-00685-2
Tuter G, Yildirim AZ, Duman AN, Aliyev B, Atak-Yucel A, Oruklu N, Kivrak E. Effects of smoking on the bone alkaline phosphatase in peri-implant crevicular fluid and implant stability quotient around implants before loading. Odontology. 2022 Jan 06; doi: 10.1007/s10266-021-00685-2. Epub 2022 Jan 06. PMID: 34993689.
Copy Download .nbib Format: NLM
Share it on

Odontology. 2022 Jan 06; doi: 10.1007/s10266-021-00685-2. Epub 2022 Jan 06.

Effects of smoking on the bone alkaline phosphatase in peri-implant crevicular fluid and implant stability quotient around implants before loading.

Odontology

Gulay Tuter, Arzu Zeynep Yildirim, Ayse Nurcan Duman, Behruz Aliyev, Aysegul Atak-Yucel, Nihan Oruklu, Elifcan Kivrak

Affiliations

  1. Faculty of Dentistry, Department of Periodontology, Gazi University, Biskek Cad. 82. Sok. Emek, Ankara, Turkey. [email protected].
  2. Faculty of Dentistry, Department of Prosthodontics, Gazi University, Ankara, Turkey.
  3. Faculty of Dentistry, Department of Periodontology, Private Practice in Ankara, Former Research Assistant at Gazi University, Ankara, Turkey.
  4. Faculty of Medicine, Department of Immunology, Gazi University, Ankara, Turkey.

PMID: 34993689 DOI: 10.1007/s10266-021-00685-2

Abstract

We aimed to examine the implant stability quotient (ISQ), alveolar bone level measurements (ABL), and bone alkaline phosphatase (BALP) in peri-implant crevicular fluid (PICF) around implants in smokers and non-smokers before loading in 3 months. 44 dental implants were placed into smoker and non-smoker patients equally. ISQ was measured at baseline and 3 months after surgery. The levels of PICF BALP and alveolar bone were measured. ISQ values significantly increased in smokers and non-smokers in the 3rd month (p < 0.05). ABL measurements were lower at 3 months compared to baseline in both groups (p < 0.05). Although ISQ and ABL values were higher in non-smokers than smokers at 3 months, the difference between the groups did not show any statistical significance. The PICF BALP levels in the 3rd month changed in both groups. But, these differences were insignificant. Although some of the measurements presented differences between the groups during the assessment periods, they were not indicative of the hazardous effects of smoking on bone healing around implants after surgery till functional loading in 3 months. However, smoking is an important factor to be considered for osseo-integration outcomes. Further studies are needed to clarify the influence of smoking on osseo-integration.

© 2022. The Society of The Nippon Dental University.

Keywords: Dental implants; Nicotine; Osseointegration; Smoking

References

  1. Levin L, Schwartz-Arad D. The effect of cigarette smoking on dental implants and related surgery. Implant Dent. 2005;14:357–61. https://doi.org/10.1097/01.id.0000187956.59276.f8 . - PubMed
  2. Palmer RM, Wilson RF, Hasan AS, Scott DA. Mechanisms of action of environmental factors-tobacco smoking. J Clin Periodontol. 2005;32:180–95. https://doi.org/10.1111/j.1600-051X.2005.00786.x . - PubMed
  3. Keenan JR, Veitz-Keenan A. The impact of smoking on failure rates, postoperative infection and marginal bone loss of dental implants. Evid Based Dent. 2016;17:4–5. https://doi.org/10.1038/sj.ebd.6401144 . - PubMed
  4. Chrcanovic BR, Albrektsson T, Wennerberg A. Smoking and dental implants: a systematic review and meta-analysis. J Dent. 2015;43:487–98. https://doi.org/10.1016/j.jdent.2015.03.003 . - PubMed
  5. Twito D, Sade P. The effect of cigarette smoking habits on the outcome of dental implant treatment. Peer J. 2014;2:e546. https://doi.org/10.7717/peerj.546 . - PubMed
  6. Gotfredsen K, Lindh CH, Berglundh T. Does long standing nicotine exposure impair bone healing and osseointegration? An experimental study in rabbits. J Biomed Mater Res B Appl Biomater. 2009;91:918–23. https://doi.org/10.1002/jbm.b.31475 . - PubMed
  7. Stefani CM, Nogueira F, Sallum EA, de Toledo S, Sallum AW, Nociti FH Jr. Influence of nicotine administration on different implant surfaces:a histometric study in rabbits. J Periodontol. 2002;73:206–12. https://doi.org/10.1902/jop.2002.73.2.206 . - PubMed
  8. Shanbhag S, Shanbhag V, Stavropoulos A. Genomic analyses of early peri-implant bone healing in humans: a systematic review. Int J Implant Dent. 2015;1(1):5. https://doi.org/10.1186/s40729-015-0006-2 . - PubMed
  9. Sharma U, Pal D, Prasad R. Alkaline phosphatase: an overview. Indian J Clin Biochem. 2014;29:269–78. https://doi.org/10.1007/s12291-013-0408-y . - PubMed
  10. Jaffin RA, Berman CL. The excessive loss of Branemark fixtures in type IV bone: a 5-year analysis. J Periodontol. 1991;62:2–4. https://doi.org/10.1902/jop.1991.62.1.2 . - PubMed
  11. Tirachaimongkol C, Pothacharoen P, Reichart PA, Khongkhunthian P. Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study. Int J Implant Dent. 2016;2:27. https://doi.org/10.1186/s40729-016-0058-y . - PubMed
  12. Manzano-Moreno FJ, Herrera-Briones FJ, Bassam T, Vallecillo-Capilla MF, Reyes-Botella C. Factors affecting dental implant stability measured using the ostell mentor device: a systematic review. Implant Dent. 2015;24(5):565–77. https://doi.org/10.1097/ID.0000000000000308 . - PubMed
  13. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4(1):1–6. https://doi.org/10.1902/annals.1999.4.1.1 . - PubMed
  14. Chapple ILC, Mealey BL, Van Dyke TE, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World workshop on the classification of periodontal and peri-implant diseases and conditions. J Clin Periodontol. 2018;45(Suppl 20):S60–77. https://doi.org/10.1111/jcpe.12940 . - PubMed
  15. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975;25(4):229–35. - PubMed
  16. Dogan SB, Kurtis MB, Tuter G, Serdar M, Watanabe K, Karakis S. Evaluation of clinical parameters and levels of proinflammatory cytokines in the crevicular fluid around dental implants in patients with type 2 diabetes mellitus. Int J Oral Maxillofac Implants. 2015;30(5):1119–27. https://doi.org/10.11607/jomi.3787 . - PubMed
  17. Liu KN, Meng HX, Lu RF, et al. Initial priodontal therapy reduced systemic and local 25-hydroxy vitamin D-3 and interleukin-1 beta in patints with aggressive periodontitis. J Periodontol. 2010;81:260–6. https://doi.org/10.1902/jop.2009.090355 . - PubMed
  18. Erdemir EO, Duran I, Haliloglu S. The enzyme activity of alkaline phosphatase in gingival crevicular fluid of smokers and non-smokers with chronic periodontitis. J Hacettepe Fac Dent. 2006;30(3):25–32. http://www.dishekdergi.hacettepe.edu.tr/htdergi/makaleler/2006sayi3makale-4.pdf - PubMed
  19. Alsaadi G, Quirynen M, Komarek A, van Steenberghe D. Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection. J Clin Periodontol. 2007;34:610–7. https://doi.org/10.1111/j.1600-051X.2007.01077.x . - PubMed
  20. Santos MCLG, Campos MIG, Line SRP. Early dental implant failure: a review of the literature. Braz J Oral Sci. 2002;1:103–11. https://doi.org/10.20396/bjos.v1i3.8641045 . - PubMed
  21. Palma-Carrio C, Maestre-Ferrín L, Peñarrocha-Oltra D, Peñarrocha-Diago MA, Peñarrocha-Diago M. Risk factors associated with early failure of dental implants. A literature review. Med Oral Patol Oral Cir Bucal. 2011;16:e514–7. https://doi.org/10.4317/medoral.16.e514 . - PubMed
  22. Bielemann AM, Marcello-Machado RM, Leite FRM, et al. Comparison between inflammation-related markers in peri-implant crevicular fluid and clinical parameters during osseointegration in edentulous jaws. Clin Oral Investig. 2018;22:531–43. https://doi.org/10.1007/s00784-017-2169-0 . - PubMed
  23. W-Dahl A, Toksvig-Larsen S. Cigarette smoking delays bone healing: a prospective study of 200 patients operated on by the hemicallotasis technique. Acta Orthop Scand. 2004;75:347–51. https://doi.org/10.1080/00016470410001303 . - PubMed
  24. Bezerra FJD, Rodrigues JA, Piattelli A, Iezzi G, Gehrke SA, Shibli JA. The effect of cigarette smoking on early osseointegration of dental implants: a prospective controlled study. Clin Oral Implants Res. 2016;27:1123–8. https://doi.org/10.1111/clr.12705 . - PubMed
  25. Sayardoust S, Omar O, Thomsen P. Gene expression in peri-implant crevicular fluid of smokers and nonsmokers. 1. The early phase of osseointegration. Clin Implant Dent Relat Res. 2017;19:681–93. https://doi.org/10.1111/cid.12486 . - PubMed
  26. Sayardoust S, Omar O, Norderyd O, Thomsen P. Clinical, radiological and gene expression analyses in smokers and nonsmokers. 2. The late healing phase of osseointegration. Clin Implant Dent Relat Res. 2017;19:901–15. https://doi.org/10.1111/cid.12514 . - PubMed
  27. Sun C, Zhao J, Jianghao C, Hong T. Effect of heavy smoking on dental implants placed in male patients posterior mandibles: a prospective clinical study. J Oral Implantol. 2016;42:477–83. https://doi.org/10.1563/aaid-joi-D-16-00078 . - PubMed
  28. Desai S, Shinde H, Mudda J, Patil V. Levels of alkaline phosphatase (ALP) in saliva of patients with chronic periodontitis; a clinical and biochemical study. Internet J Dent Sci. 2008;8:1–7. - PubMed
  29. Plagnat D, Giannopoulou C, Carrel A, Bernard JP, Mombelli A, Belser UC. Elastase, α2-macroglobulin and alkaline phosphatase in crevicular fluid from implants with and without periimplantitis. Clin Oral Implants Res. 2002;3:227–33. https://doi.org/10.1034/j.1600-0501.2002.130301.x . - PubMed
  30. Swati D, Udayan G, Vidya D, Bhavna KJ, Prafull GD. The enzyme activity of alkaline phosphatase in gingival crevicular fluid of smokers and non-smokers with chronic periodontitis before and after phase I therapy. J Pharm Biomed Sci. 2013;32:1348–1353. Available at http://www.jpbms.info - PubMed
  31. Grover V, Malhotra R, Kapoor A, Bither R, Sachdeva S. Correlation of alkaline phosphatase activity to clinical parameters of inflammation in smokers suffering from chronic periodontitis. J Indian Soc Periodontol. 2016;20:254–9. https://doi.org/10.4103/0972-124X.183099 . - PubMed
  32. Gao J, Symons AL, Haase H, Bartold PM. Should cementoblasts express alkaline phosphatase activity? Preliminary study of rat cementoblasts in vitro. J Periodontol. 1999;70:951–9. https://doi.org/10.1902/jop.1999.70.9.951 . - PubMed
  33. Sayardoust S. The effect of tobacco exposure on bone healing and the osseointegration of dental implants, clinical and molecular studies. [Thesis]. Gothenburg, Sweden: University of Gothenburg. 2017. 56 p. http://hdl.handle.net/2077/51881 . - PubMed
  34. Giannopoulou C, Geinoz A, Cimasoni G. Effects of nicotine on periodontal ligament fibroblasts in vitro. J Clin Periodontol. 1999;26:49–55. https://doi.org/10.1034/j.1600-051x.1999.260109.x . - PubMed
  35. Paknejad M, Emtiaz S, Khoobyari MM, Gharb MT, Yazdi MT. Analysis of aspartate aminotransferase and alkaline phosphatase in crevicular fluid from implants with and without peri-implantitis. Implant Dent. 2006;15:62–9. https://doi.org/10.1097/01.id.0000202416.23259.35 . - PubMed
  36. Yamano S, Berley JA, Kuo WP, Gallucci GO, Weber HP, Sukotjo C. Effects of nicotine on gene expression and osseointegration in rats. Clin Oral Implants Res. 2010;21:1353–9. https://doi.org/10.1111/j.1600-0501.2010.01955.x . - PubMed

Publication Types

Grant support