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Yildirim C, Cevik S, Yamaner H, et al. Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats. J Trace Elem Med Biol. 2021;70:126917doi: 10.1016/j.jtemb.2021.126917.
Yildirim, C., Cevik, S., Yamaner, H., Orkmez, M., Eronat, O., Bozdayı, M. A., & Erdem, M. (2021). Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 70126917. https://doi.org/10.1016/j.jtemb.2021.126917
Yildirim, Caner, et al. "Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats." Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) vol. 70 (2021): 126917. doi: https://doi.org/10.1016/j.jtemb.2021.126917
Yildirim C, Cevik S, Yamaner H, Orkmez M, Eronat O, Bozdayı MA, Erdem M. Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats. J Trace Elem Med Biol. 2021 Dec 23;70:126917. doi: 10.1016/j.jtemb.2021.126917. Epub 2021 Dec 23. PMID: 34963081.
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J Trace Elem Med Biol. 2021 Dec 23;70:126917. doi: 10.1016/j.jtemb.2021.126917. Epub 2021 Dec 23.

Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Caner Yildirim, Sena Cevik, Hatice Yamaner, Mustafa Orkmez, Omer Eronat, Mehmet Akif Bozdayı, Mehmet Erdem

Affiliations

  1. Gaziantep University, Faculty of Medicine, Department of Physiology, Gaziantep, Turkey. Electronic address: [email protected].
  2. Gaziantep University, Faculty of Medicine, Department of Physiology, Gaziantep, Turkey. Electronic address: [email protected].
  3. Gaziantep University, Faculty of Medicine, Department of Physiology, Gaziantep, Turkey. Electronic address: [email protected].
  4. Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry, Gaziantep, Turkey. Electronic address: [email protected].
  5. Gaziantep University, Faculty of Medicine, Department of Pathology, Gaziantep, Turkey. Electronic address: [email protected].
  6. Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry, Gaziantep, Turkey. Electronic address: [email protected].
  7. Gaziantep University, Vocational School of Health Services, Gaziantep, Turkey. Electronic address: [email protected].

PMID: 34963081 DOI: 10.1016/j.jtemb.2021.126917

Abstract

Boric acid (BA) has been used in many diseases because it increases the amount of reduced glutathione in the body and reduces oxidative damage. This study aims to investigate the effects of boric acid in cisplatin-induced neuropathy, in which oxidative stress is also effective in its pathophysiology. In this study, 8-10 weeks old, 170-190 g Wistar Albino rats were used. Each group contained seven rats (n = 35). Experimental groups consist of control, sham, neuropathy, treatment, and boric acid groups. For the neuropathy model, a single dose of cisplatin (3 mg/kg, i.p) was administered once a week for five weeks, and for the treatment group, boric acid was administered daily (100 mg/kg, intragastric) for five weeks. After drug administration, the rotarod test to evaluate motor performance, the tail-flick and hot/cold plate tests to evaluate sensory conduction states, the von Frey filament test to evaluate the mechanical allodynia, and the adhesive removal test to assess sensorimotor function were performed. The sciatic nerve's motoric conduction velocity was also assessed electrophysiologically. Oxidative stress parameters were also assessed biochemically in sciatic nerve tissue and serum. Hematoxylin and eosin staining was used to evaluate the sciatic nerve tissue histopathologically. The motor conduction velocity of the sciatic nerve, impaired by cisplatin, was increased considerably by boric acid (p < 0.05). It also reduced the latency time of the compound muscle action potential (CMAP), which was increased by cisplatin. (p < 0.05). The von Frey filament test results demonstrated increased pain sensitivity of the cisplatin group increased, and mechanical allodynia was observed. Boric acid significantly alleviated this condition (p < 0.05). In the cold plate, adhesive removal, and rotarod tests, boric acid attenuated the adverse effects of cisplatin (p < 0.05). Biochemically, BA reduced the level of MDA, which was raised by cisplatin, and significantly increased the level of SOD, which was lowered by cisplatin (p < 0.05). Histopathologically; BA reduced neuronal degeneration and vacuolization caused by cisplatin. As a consequence, it has been determined that boric acid alleviates the adverse effects of cisplatin. BA reduced the destructive effect of cisplatin by reducing oxidative stress, and this effect was verified electrophysiologically, behaviorally, and histopathologically.

Copyright © 2021 Elsevier GmbH. All rights reserved.

Keywords: Boric acid; Cisplatin; Electrophysiology; Nerve conduction velocity; Neuropathy

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