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Kouyoumdzian NM, Kim G, Rudi MJ, et al. Clues and new evidences in arterial hypertension: unmasking the role of the chloride anion. Pflugers Arch. 2021;474(1):155-176doi: 10.1007/s00424-021-02649-5.
Kouyoumdzian, N. M., Kim, G., Rudi, M. J., Rukavina Mikusic, N. L., Fernández, B. E., & Choi, M. R. (2022). Clues and new evidences in arterial hypertension: unmasking the role of the chloride anion. Pflugers Archiv : European journal of physiology, 474(1), 155-176. https://doi.org/10.1007/s00424-021-02649-5
Kouyoumdzian, Nicolás Martín, et al. "Clues and new evidences in arterial hypertension: unmasking the role of the chloride anion." Pflugers Archiv : European journal of physiology vol. 474,1 (2022): 155-176. doi: https://doi.org/10.1007/s00424-021-02649-5
Kouyoumdzian NM, Kim G, Rudi MJ, Rukavina Mikusic NL, Fernández BE, Choi MR. Clues and new evidences in arterial hypertension: unmasking the role of the chloride anion. Pflugers Arch. 2022 Jan;474(1):155-176. doi: 10.1007/s00424-021-02649-5. Epub 2021 Dec 30. PMID: 34966955.
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Pflugers Arch. 2022 Jan;474(1):155-176. doi: 10.1007/s00424-021-02649-5. Epub 2021 Dec 30.

Clues and new evidences in arterial hypertension: unmasking the role of the chloride anion.

Pflugers Archiv : European journal of physiology

Nicolás Martín Kouyoumdzian, Gabriel Kim, María Julieta Rudi, Natalia Lucía Rukavina Mikusic, Belisario Enrique Fernández, Marcelo Roberto Choi

Affiliations

  1. Universidad de Buenos Aires, CONICET, Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET), Buenos Aires, Argentina. [email protected].
  2. Facultad de Farmacia Y Bioquímica, Departamento de Ciencias Biológicas, Cátedra de Anatomía e Histología, Universidad de Buenos Aires, Buenos Aires, Argentina.
  3. Instituto Universitario de Ciencias de La Salud, Fundación H.A. Barceló, Buenos Aires, Argentina.
  4. Universidad de Buenos Aires, CONICET, Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET), Buenos Aires, Argentina.

PMID: 34966955 DOI: 10.1007/s00424-021-02649-5

Abstract

The present review will focus on the role of chloride anion in cardiovascular disease, with special emphasis in the development of hypertensive disease and vascular inflammation. It is known that acute and chronic overload of sodium chloride increase blood pressure and have pro-inflammatory and pro-fibrotic effects on different target organs, but it is unknown how chloride may influence these processes. Chloride anion is the predominant anion in the extracellular fluid and its intracellular concentration is dynamically regulated. As the queen of the electrolytes, it is of crucial importance to understand the physiological mechanisms that regulate the cellular handling of this anion including the different transporters and cellular chloride channels, which exert a variety of functions, such as regulation of cellular proliferation, differentiation, migration, apoptosis, intracellular pH and cellular redox state. In this article, we will also review the relationship between dietary, serum and intracellular chloride and how these different sources of chloride in the organism are affected in hypertension and their impact on cardiovascular disease. Additionally, we will discuss the approach of potential strategies that affect chloride handling and its potential effect on cardiovascular system, including pharmacological blockade of chloride channels and non-pharmacological interventions by replacing chloride by another anion.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords: Chloride anion; Chloride channels; Hypertension; Pharmacological and non-pharmacological interventions; Target organ damage

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