Int J Cardiovasc Imaging. 2022 Jan 07; doi: 10.1007/s10554-021-02520-9. Epub 2022 Jan 07.

Normal ranges of left atrial volumes and ejection fraction by 3D echocardiography in adults: a systematic review and meta-analysis.

The international journal of cardiovascular imaging

Stefano Figliozzi, Georgios Georgiopoulos, Kostantinos Pateras, Alexandros Sianis, Marco Previtero, Lara Tondi, Ιoannis Petropoulos, Renato Maria Bragato, Alexandros Papachristidis, Gianluigi Condorelli, Masaaki Takeuchi

PMID: 34994882 DOI: 10.1007/s10554-021-02520-9

Abstract

Increased sizes and dysfunction of the left atrium have been related to adverse outcomes. 3D-echocardiography is more accurate than 2D-echocardiography in estimating LA volumes and ejection fraction. However, the use of 3DE for LA analysis is limited by the absence of established reference values. We performed a systematic review and meta-analysis to provide reference ranges of LA maximum and minimum volumes indexed for body surface area (LAVi max and LAVi min, respectively), and LA-EF assessed by 3DE in healthy adults. Data search was conducted from inception through September 15, 2021, using the following Medical Subject Heading terms: left atrial/atrium, three-dimensional/3D echocardiography. The study protocol was registered in the PROSPERO database (CRD42021252428). 15 studies including 4,226 healthy adults (51% males) and reporting 3DE values of LAVi max, LAVi min and LA-EF were selected. LAVi max, LAVi min and LA-EF mean and reference values were equal to 25.18 ml/m

© 2022. The Author(s), under exclusive licence to Springer Nature B.V.

Keywords: 3D-echocardiography; Ejection fraction; Left atrium; Normal values; Three-dimensional echocardiography; Volume

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Publication Types

• Journal Article

Grant support

• Training grant 2021/European Association of Cardiovascular Imaging (EACVI)
• Special grant/Alexander S. Onassis Public Benefit Foundation
• support program for scholars' association members (GRANT No. R ZP 001/2019-2020)/Alexander S. Onassis Public Benefit Foundation