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Manjili MH, Khazaie K. Pattern recognition of tumor dormancy and relapse beyond cell-intrinsic and cell-extrinsic pathways. Semin Cancer Biol. 2022;doi: 10.1016/j.semcancer.2021.12.008.
Manjili, M. H., & Khazaie, K. (2022). Pattern recognition of tumor dormancy and relapse beyond cell-intrinsic and cell-extrinsic pathways. Seminars in cancer biology, . https://doi.org/10.1016/j.semcancer.2021.12.008
Manjili, Masoud H, and Khazaie, Khashayarsha. "Pattern recognition of tumor dormancy and relapse beyond cell-intrinsic and cell-extrinsic pathways." Seminars in cancer biology vol. (2022). doi: https://doi.org/10.1016/j.semcancer.2021.12.008
Manjili MH, Khazaie K. Pattern recognition of tumor dormancy and relapse beyond cell-intrinsic and cell-extrinsic pathways. Semin Cancer Biol. 2022 Jan 03; doi: 10.1016/j.semcancer.2021.12.008. Epub 2022 Jan 03. PMID: 34990835.
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Semin Cancer Biol. 2022 Jan 03; doi: 10.1016/j.semcancer.2021.12.008. Epub 2022 Jan 03.

Pattern recognition of tumor dormancy and relapse beyond cell-intrinsic and cell-extrinsic pathways.

Seminars in cancer biology

Masoud H Manjili, Khashayarsha Khazaie

Affiliations

  1. Department of Microbiology & Immunology, VCU School of Medicine, Massey Cancer Center, 401 College Street, Box 980035, Richmond, VA, 23298, United States. Electronic address: [email protected].
  2. Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, United States.

PMID: 34990835 DOI: 10.1016/j.semcancer.2021.12.008

Abstract

In this thematic issue, several mechanisms of tumor dormancy and relapse are discussed. The reviews suggest mutual interactions and communications between malignant cells and other cells in their niche during tumor dormancy. Nevertheless, a complete understanding of tumor dormancy remains elusive. This is because we are getting lost in details of cell-intrinsic and cell-extrinsic molecular pathways without being able to discover the pattern of tumor dormancy. Here, we discuss some conceptual frameworks and methodological approaches that facilitate pattern recognition of tumor dormancy, and propose that settling on certain biological scale such as mitochondria would be the key to discover the pattern of tumor dormancy and relapse.

Copyright © 2021. Published by Elsevier Ltd.

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