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Davoodvandi A, Fallahi F, Tamtaji OR, et al. An Update on the Effects of Probiotics on Gastrointestinal Cancers. Front Pharmacol. 2021;12:680400doi: 10.3389/fphar.2021.680400.
Davoodvandi, A., Fallahi, F., Tamtaji, O. R., Tajiknia, V., Banikazemi, Z., Fathizadeh, H., Abbasi-Kolli, M., Aschner, M., Ghandali, M., Sahebkar, A., Taghizadeh, M., & Mirzaei, H. (2021). An Update on the Effects of Probiotics on Gastrointestinal Cancers. Frontiers in pharmacology, 12680400. https://doi.org/10.3389/fphar.2021.680400
Davoodvandi, Amirhossein, et al. "An Update on the Effects of Probiotics on Gastrointestinal Cancers." Frontiers in pharmacology vol. 12 (2021): 680400. doi: https://doi.org/10.3389/fphar.2021.680400
Davoodvandi A, Fallahi F, Tamtaji OR, Tajiknia V, Banikazemi Z, Fathizadeh H, Abbasi-Kolli M, Aschner M, Ghandali M, Sahebkar A, Taghizadeh M, Mirzaei H. An Update on the Effects of Probiotics on Gastrointestinal Cancers. Front Pharmacol. 2021 Dec 21;12:680400. doi: 10.3389/fphar.2021.680400. eCollection 2021. PMID: 34992527; PMCID: PMC8724544.
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Front Pharmacol. 2021 Dec 21;12:680400. doi: 10.3389/fphar.2021.680400. eCollection 2021.

An Update on the Effects of Probiotics on Gastrointestinal Cancers.

Frontiers in pharmacology

Amirhossein Davoodvandi, Farzaneh Fallahi, Omid Reza Tamtaji, Vida Tajiknia, Zarrin Banikazemi, Hadis Fathizadeh, Mohammad Abbasi-Kolli, Michael Aschner, Maryam Ghandali, Amirhossein Sahebkar, Mohsen Taghizadeh, Hamed Mirzaei

Affiliations

  1. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
  2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  4. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  5. Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  6. Department of Laboratory Sciences, Sirjan Faculty of Medicine Sciences, Sirjan, Iran.
  7. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  8. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.
  9. School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 34992527 PMCID: PMC8724544 DOI: 10.3389/fphar.2021.680400

Abstract

Because of their increasing prevalence, gastrointestinal (GI) cancers are regarded as an important global health challenge. Microorganisms residing in the human GI tract, termed gut microbiota, encompass a large number of living organisms. The role of the gut in the regulation of the gut-mediated immune responses, metabolism, absorption of micro- and macro-nutrients and essential vitamins, and short-chain fatty acid production, and resistance to pathogens has been extensively investigated. In the past few decades, it has been shown that microbiota imbalance is associated with the susceptibility to various chronic disorders, such as obesity, irritable bowel syndrome, inflammatory bowel disease, asthma, rheumatoid arthritis, psychiatric disorders, and various types of cancer. Emerging evidence has shown that oral administration of various strains of probiotics can protect against cancer development. Furthermore, clinical investigations suggest that probiotic administration in cancer patients decreases the incidence of postoperative inflammation. The present review addresses the efficacy and underlying mechanisms of action of probiotics against GI cancers. The safety of the most commercial probiotic strains has been confirmed, and therefore these strains can be used as adjuvant or neo-adjuvant treatments for cancer prevention and improving the efficacy of therapeutic strategies. Nevertheless, well-designed clinical studies are still needed for a better understanding of the properties and mechanisms of action of probiotic strains in mitigating GI cancer development.

Copyright © 2021 Davoodvandi, Fallahi, Tamtaji, Tajiknia, Banikazemi, Fathizadeh, Abbasi-Kolli, Aschner, Ghandali, Sahebkar, Taghizadeh and Mirzaei.

Keywords: cancer; gastrointestinal disorders; pathology; probiotic; therapy

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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