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Rostamian S, le Cessie S, Marijt KA, et al. Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. PLoS One. 2022;17(1):e0261826doi: 10.1371/journal.pone.0261826.
Rostamian, S., le Cessie, S., Marijt, K. A., Jukema, J. W., Mooijaart, S. P., van Buchem, M. A., van Hall, T., Gussekloo, J., & Trompet, S. (2022). Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. PloS one, 17(1), e0261826. https://doi.org/10.1371/journal.pone.0261826
Rostamian, Somayeh, et al. "Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies." PloS one vol. 17,1 (2022): e0261826. doi: https://doi.org/10.1371/journal.pone.0261826
Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S. Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. PLoS One. 2022 Jan 07;17(1):e0261826. doi: 10.1371/journal.pone.0261826. eCollection 2022. PMID: 34995287; PMCID: PMC8741047.
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PLoS One. 2022 Jan 07;17(1):e0261826. doi: 10.1371/journal.pone.0261826. eCollection 2022.

Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies.

PloS one

Somayeh Rostamian, Saskia le Cessie, Koen A Marijt, J Wouter Jukema, Simon P Mooijaart, Mark A van Buchem, Thorbald van Hall, Jacobijn Gussekloo, Stella Trompet

Affiliations

  1. Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
  2. Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands.
  3. Department of Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
  4. Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
  5. Department of Clinical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.
  6. Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.

PMID: 34995287 PMCID: PMC8741047 DOI: 10.1371/journal.pone.0261826

Abstract

BACKGROUND: Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies were conducted to evaluate the association of cognitive function and risk of cancer death.

METHODS: Risk of cancer death and all-cause mortality were reported using hazard ratios (HRs) with 95% confidence interval (CI) in tertiles of cognitive function of PROSPER and Leiden85-Plus Study. Additionally, PubMed, Embase, Web of Science, Cochrane, PsycINFO, Academic Search Premier, CINHAL, and Emcare were searched up to November 1st, 2020 to perform a systematic review and meta-analysis. The relative risks (RRs) with 95%CI of cancer death per each standard deviation lower performance in cognitive measurements were calculated.

RESULTS: Participants of PROSPER had 1.65-fold (95%CI 1.11-2.47) greater risk of cancer death (P for trend = 0.016) and 1.85-fold (95%CI 1.46-2.34) higher risk of all-cause mortality (P for trend<0.001), in multivariable models. Results of the Leiden-85 Plus Study showed that subjects with MMSE score below 24 had a lower chance of cancer death (HR 0.79, 95%CI 0.36-1.70, P for trend = 0.820) but had 2.18-fold (95%CI 1.57-3.02) higher risk of all-cause mortality compared to the reference group (P for trend<0.001). Besides, the results of systematic review and meta-analysis showed that per each standard deviation lower performance in cognitive function, individuals were at a 10% higher chance of cancer death (RR 1.10, 95%CI 1.00-1.20, P-value = 0.044).

CONCLUSIONS: Lower cognitive function performance is associated with a marginally increased risk of cancer death, in line with a significantly greater risk of all-cause mortality.

Conflict of interest statement

The authors have declared that no competing interests exist.

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