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Bitencourt TA, Hatanaka O, Pessoni AM, et al. Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication. mBio. 2022;e0327221doi: 10.1128/mbio.03272-21.
Bitencourt, T. A., Hatanaka, O., Pessoni, A. M., Freitas, M. S., Trentin, G., Santos, P., Rossi, A., Martinez-Rossi, N. M., Alves, L. L., Casadevall, A., Rodrigues, M. L., & Almeida, F. (2022). Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication. mBio, e0327221. https://doi.org/10.1128/mbio.03272-21
Bitencourt, Tamires A, et al. "Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication." mBio vol. (2022): e0327221. doi: https://doi.org/10.1128/mbio.03272-21
Bitencourt TA, Hatanaka O, Pessoni AM, Freitas MS, Trentin G, Santos P, Rossi A, Martinez-Rossi NM, Alves LL, Casadevall A, Rodrigues ML, Almeida F. Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication. mBio. 2022 Jan 11;e0327221. doi: 10.1128/mbio.03272-21. Epub 2022 Jan 11. PMID: 35012355.
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mBio. 2022 Jan 11;e0327221. doi: 10.1128/mbio.03272-21. Epub 2022 Jan 11.

Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication.

mBio

Tamires A Bitencourt, Otavio Hatanaka, Andre M Pessoni, Mateus S Freitas, Gabriel Trentin, Patrick Santos, Antonio Rossi, Nilce M Martinez-Rossi, Lysangela L Alves, Arturo Casadevall, Marcio L Rodrigues, Fausto Almeida

Affiliations

  1. Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
  2. Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  3. Gene Expression Regulation Laboratory, Carlos Chagas Institute, Fiocruz, Curitiba, PR, Brazil.
  4. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  5. Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

PMID: 35012355 DOI: 10.1128/mbio.03272-21

Abstract

Fungal infections are associated with high mortality rates in humans. The risk of fungal diseases creates the urgent need to broaden the knowledge base regarding their pathophysiology. In this sense, the role of extracellular vesicles (EVs) has been described to convey biological information and participate in the fungus-host interaction process. We hypothesized that fungal EVs work as an additional element in the communication routes regulating fungal responses in intraspecies interaction systems. In this respect, the aim of this study was to address the gene regulation profiles prompted by fungal EVs in intraspecies recipient cells. Our data demonstrated the intraspecies uptake of EVs in pathogenic fungi, such as Candida albicans, Aspergillus fumigatus, and Paracoccidioides brasiliensis, and the effects triggered by EVs in fungal cells. In C. albicans, we evaluated the involvement of EVs in the yeast-to-hypha transition, while in

Keywords: Aspergillus fumigatus; Candida albicans; Paracoccidioides brasiliensis; cellular communication; extracellular vesicles; fungal biology; fungal infections

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