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Martin SS, Muscogiuri E, Burchett PF, et al. Tumorous tissue characterization using integrated 18F-FDG PET/dual-energy CT in lung cancer: Combining iodine enhancement and glycolytic activity. Eur J Radiol. 2021;110116doi: 10.1016/j.ejrad.2021.110116.
Martin, S. S., Muscogiuri, E., Burchett, P. F., van Assen, M., Tessarin, G., Vogl, T. J., Schoepf, U. J., & De Cecco, C. N. (2021). Tumorous tissue characterization using integrated 18F-FDG PET/dual-energy CT in lung cancer: Combining iodine enhancement and glycolytic activity. European journal of radiology, 110116. https://doi.org/10.1016/j.ejrad.2021.110116
Martin, Simon S, et al. "Tumorous tissue characterization using integrated 18F-FDG PET/dual-energy CT in lung cancer: Combining iodine enhancement and glycolytic activity." European journal of radiology vol. (2021): 110116. doi: https://doi.org/10.1016/j.ejrad.2021.110116
Martin SS, Muscogiuri E, Burchett PF, van Assen M, Tessarin G, Vogl TJ, Schoepf UJ, De Cecco CN. Tumorous tissue characterization using integrated 18F-FDG PET/dual-energy CT in lung cancer: Combining iodine enhancement and glycolytic activity. Eur J Radiol. 2021 Dec 23;110116. doi: 10.1016/j.ejrad.2021.110116. Epub 2021 Dec 23. PMID: 34996651.
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Eur J Radiol. 2021 Dec 23;110116. doi: 10.1016/j.ejrad.2021.110116. Epub 2021 Dec 23.

Tumorous tissue characterization using integrated 18F-FDG PET/dual-energy CT in lung cancer: Combining iodine enhancement and glycolytic activity.

European journal of radiology

Simon S Martin, Emanuele Muscogiuri, Philip F Burchett, Marly van Assen, Giovanni Tessarin, Thomas J Vogl, U Joseph Schoepf, Carlo N De Cecco

Affiliations

  1. Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany.
  2. Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA; Institute of Radiology, University of Rome "Sapienza", Rome, Italy.
  3. Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
  4. Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
  5. Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA; Department of Medicine-DIMED, Institute of Radiology, University of Padova, Italy.
  6. Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA. Electronic address: [email protected].

PMID: 34996651 DOI: 10.1016/j.ejrad.2021.110116

Abstract

Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) has become the method of choice for tumor staging in lung cancer patients with improved diagnostic accuracy for the evaluation of lymph node involvement and distant metastasis. Due to its spectral capabilities, dual-energy CT (DECT) employs a material decomposition algorithm enabling precise quantification of iodine concentrations in distinct tissues. This technique enhances the characterization of tumor blood supply and has demonstrated promising results for the assessment of therapy response in patients with lung cancer. Several studies have demonstrated that DECT provides additional value to the PET-based evaluation of glycolytic activity, especially for the evaluation of therapy response and follow-up of patients with lung cancer. The combination of PET and DECT in a single scanner system enables the simultaneous assessment of glycolytic activity and iodine enhancement, offering further insight to the characterization of tumorous tissues. Recently a new approach of a novel integrated PET/DECT was investigated in a pilot study on patients with non-small cell lung cancer (NSCLC). The study showed a moderate correlation between PET-based standard uptake values (SUV) and DECT-based iodine densities in the evaluation of lung tumorous tissue but with limited assessment of lymph nodes. The following review on tumorous tissue characterization using PET and DECT imaging describes the strengths and limitations of this novel technique.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Dual-energy computed tomography; Lung neoplasms; Molecular imaging; Positron-emission tomography; Spectral imaging

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